Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings

Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings

L-arginine/nitric oxide pathway in Crohn’s disease (CD) and ulcerative colitis (UC) is poorly investigated. The aim of current study is to quantify pathway serum metabolites in 52 CD (40 active), 48 UC (33 active), and 18 irritable bowel syndrome patients and 40 controls using mass spectro...

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Bibliographic Details
Main Authors: Małgorzata Krzystek-Korpacka, Mariusz G. Fleszar, Iwona Bednarz-Misa, Łukasz Lewandowski, Izabela Szczuka, Radosław Kempiński, Katarzyna Neubauer
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
crohn’s disease
ulcerative colitis
arginase (arg)
nitric oxide synthase (nos)
arginine <i>n</i>-methyltransferase (prmt)
dimethylarginine dimethylaminohydrolase (ddah)
asymmetric dimethylarginine (adma)
symmetric dimethylarginine (sdma)
l-citrulline
dimethylamine (dma)
Online Access:https://www.mdpi.com/1422-0067/21/5/1641

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https://www.mdpi.com/1422-0067/21/5/1641

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