Interferon-Mediated Response to Human Metapneumovirus Infection

Human metapneumovirus (HMPV) is one of the leading causes of respiratory diseases in infants and children worldwide. Although this pathogen infects mainly young children, elderly and immunocompromised people can be also seriously affected. To date, there is no commercial vaccine available against it...

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Main Authors:	Ifeanyi K. Uche, Antonieta Guerrero-Plata
Format:	Article
Language:	English
Published:	MDPI AG 2018-09-01
Series:	Viruses
Subjects:	human metapneumovirus HMPV interferon IFN pneumovirus respiratory
Online Access:	http://www.mdpi.com/1999-4915/10/9/505

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spelling	doaj-75adb95180a446c8b1e0496db37050de2020-11-24T21:38:51ZengMDPI AGViruses1999-49152018-09-0110950510.3390/v10090505v10090505Interferon-Mediated Response to Human Metapneumovirus InfectionIfeanyi K. Uche0Antonieta Guerrero-Plata1Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USADepartment of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USAHuman metapneumovirus (HMPV) is one of the leading causes of respiratory diseases in infants and children worldwide. Although this pathogen infects mainly young children, elderly and immunocompromised people can be also seriously affected. To date, there is no commercial vaccine available against it. Upon HMPV infection, the host innate arm of defense produces interferons (IFNs), which are critical for limiting HMPV replication. In this review, we offer an updated landscape of the HMPV mediated-IFN response in different models as well as some of the defense tactics employed by the virus to circumvent IFN response.http://www.mdpi.com/1999-4915/10/9/505human metapneumovirusHMPVinterferonIFNpneumovirusrespiratory
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ifeanyi K. Uche Antonieta Guerrero-Plata
spellingShingle	Ifeanyi K. Uche Antonieta Guerrero-Plata Interferon-Mediated Response to Human Metapneumovirus Infection Viruses human metapneumovirus HMPV interferon IFN pneumovirus respiratory
author_facet	Ifeanyi K. Uche Antonieta Guerrero-Plata
author_sort	Ifeanyi K. Uche
title	Interferon-Mediated Response to Human Metapneumovirus Infection
title_short	Interferon-Mediated Response to Human Metapneumovirus Infection
title_full	Interferon-Mediated Response to Human Metapneumovirus Infection
title_fullStr	Interferon-Mediated Response to Human Metapneumovirus Infection
title_full_unstemmed	Interferon-Mediated Response to Human Metapneumovirus Infection
title_sort	interferon-mediated response to human metapneumovirus infection
publisher	MDPI AG
series	Viruses
issn	1999-4915
publishDate	2018-09-01
description	Human metapneumovirus (HMPV) is one of the leading causes of respiratory diseases in infants and children worldwide. Although this pathogen infects mainly young children, elderly and immunocompromised people can be also seriously affected. To date, there is no commercial vaccine available against it. Upon HMPV infection, the host innate arm of defense produces interferons (IFNs), which are critical for limiting HMPV replication. In this review, we offer an updated landscape of the HMPV mediated-IFN response in different models as well as some of the defense tactics employed by the virus to circumvent IFN response.
topic	human metapneumovirus HMPV interferon IFN pneumovirus respiratory
url	http://www.mdpi.com/1999-4915/10/9/505
work_keys_str_mv	AT ifeanyikuche interferonmediatedresponsetohumanmetapneumovirusinfection AT antonietaguerreroplata interferonmediatedresponsetohumanmetapneumovirusinfection
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Interferon-Mediated Response to Human Metapneumovirus Infection

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