The characteristics of HIV-positive patients with mild/asymptomatic and moderate/severe course of COVID-19 disease—A report from Central and Eastern Europe
Background: There is currently no evidence suggesting that COVID-19 takes a different course in HIV-positive patients on antiretroviral treatment compared to the general population. However, little is known about the relation between specific HIV-related factors and the severity of the COVID-19 dise...
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doaj-75b13fd9071243feae639e0f2babf0eb2021-03-27T04:25:24ZengElsevierInternational Journal of Infectious Diseases1201-97122021-03-01104293296The characteristics of HIV-positive patients with mild/asymptomatic and moderate/severe course of COVID-19 disease—A report from Central and Eastern EuropeJustyna D. Kowalska0Kerstin Kase1Anna Vassilenko2Arjan Harxhi3Botond Lakatos4Gordana Dragović Lukić5Antonija Verhaz6Nina Yancheva7Florentina Dumitrescu8David Jilich9Ladislav Machala10Agata Skrzat-Klapaczyńska11Raimonda Matulionyte12Department of Adults’ Infectious Diseases, Hospital for Infectious Diseases, Medical University of Warsaw, Poland; Corresponding author at: Medical University of Warsaw, Ul. Wolska 37, 01-201 Warsaw, Poland.West Tallinn Central Hospital, EstoniaBelarusian State Medical University, Minsk, BelarusUniversity Hospital Center of Tirana, Infectious Disease Service, AlbaniaNational Institute of Hematology and Infectious Diseases, South-Pest Central Hospital, National Center of HIV, HungaryDepartment of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, SerbiaClinic for Infectious Diseases, University Clinical Centre of the Republic of Srpska, Banja Luka, The Republic of Srpska, Bosnia and Herzegovina; Department for Infectious Diseases, Faculty of Medicine, University of Banja Luka, Banja Luka, The Republic of Srpska, Bosnia and HerzegovinaDepartment for AIDS, Specialized Hospital for Active Treatment of Infectious and Parasitic Disease Sofia, BulgariaUniversity of Medicine and Pharmacy Craiova, RomaniaDepartment of Infectious Diseases, 1st Faculty of Medicine, Charles University in Prague and Na Bulovce Hospital, Czech RepublicDepartment of Infectious Diseases, 3rd Faculty of Medicine, Charles University in Prague and Na BuLovce Hospital, Czech RepublicDepartment of Adults’ Infectious Diseases, Hospital for Infectious Diseases, Medical University of Warsaw, PolandDepartment of Infectious Diseases and Dermatovenerology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LithuaniaBackground: There is currently no evidence suggesting that COVID-19 takes a different course in HIV-positive patients on antiretroviral treatment compared to the general population. However, little is known about the relation between specific HIV-related factors and the severity of the COVID-19 disease. Methods: We performed a retrospective analysis of cases collected through an on-line survey distributed by the Euroguidelines in Central and Eastern Europe Network Group. In statistical analyses characteristics of HIV-positive patients, asymptomatic/moderate and moderate/severe course were compared. Results: In total 34 HIV-positive patients diagnosed with COVID-19 were reported by 12 countries (Estonia, Czech Republic, Lithuania, Albania, Belarus, Romania, Serbia, Bosnia and Herzegovina, Poland, Russia, Hungary, Bulgaria). Asymptomatic courses of COVID-19 were reported in four (12%) cases, 11 (32%) patients presented with mild disease not requiring hospitalization, moderate disease with respiratory and/or systemic symptoms was observed in 14 (41%) cases, and severe disease with respiratory failure was found in five (15%) patients. The HIV-related characteristics of patients with an asymptomatic/mild course of COVID-19 were comparable to those with a moderate/severe course of COVID-19, except for the use of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in cART regimen (0.0% vs. 31.6% respectively, p = 0.0239). Conclusions: In our analyses HIV viral suppression and immunological status were not associated with the course of COVID-19 disease. On the contrary the cART regimen could contribute to severity of SARS-CoV-2 infection. Large and prospective studies are necessary to further investigate this relationship.http://www.sciencedirect.com/science/article/pii/S1201971220325480HIVSARS-CoV-2COVID-19Antiretroviral therapyProtease inhibitors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Justyna D. Kowalska Kerstin Kase Anna Vassilenko Arjan Harxhi Botond Lakatos Gordana Dragović Lukić Antonija Verhaz Nina Yancheva Florentina Dumitrescu David Jilich Ladislav Machala Agata Skrzat-Klapaczyńska Raimonda Matulionyte |
spellingShingle |
Justyna D. Kowalska Kerstin Kase Anna Vassilenko Arjan Harxhi Botond Lakatos Gordana Dragović Lukić Antonija Verhaz Nina Yancheva Florentina Dumitrescu David Jilich Ladislav Machala Agata Skrzat-Klapaczyńska Raimonda Matulionyte The characteristics of HIV-positive patients with mild/asymptomatic and moderate/severe course of COVID-19 disease—A report from Central and Eastern Europe International Journal of Infectious Diseases HIV SARS-CoV-2 COVID-19 Antiretroviral therapy Protease inhibitors |
author_facet |
Justyna D. Kowalska Kerstin Kase Anna Vassilenko Arjan Harxhi Botond Lakatos Gordana Dragović Lukić Antonija Verhaz Nina Yancheva Florentina Dumitrescu David Jilich Ladislav Machala Agata Skrzat-Klapaczyńska Raimonda Matulionyte |
author_sort |
Justyna D. Kowalska |
title |
The characteristics of HIV-positive patients with mild/asymptomatic and moderate/severe course of COVID-19 disease—A report from Central and Eastern Europe |
title_short |
The characteristics of HIV-positive patients with mild/asymptomatic and moderate/severe course of COVID-19 disease—A report from Central and Eastern Europe |
title_full |
The characteristics of HIV-positive patients with mild/asymptomatic and moderate/severe course of COVID-19 disease—A report from Central and Eastern Europe |
title_fullStr |
The characteristics of HIV-positive patients with mild/asymptomatic and moderate/severe course of COVID-19 disease—A report from Central and Eastern Europe |
title_full_unstemmed |
The characteristics of HIV-positive patients with mild/asymptomatic and moderate/severe course of COVID-19 disease—A report from Central and Eastern Europe |
title_sort |
characteristics of hiv-positive patients with mild/asymptomatic and moderate/severe course of covid-19 disease—a report from central and eastern europe |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2021-03-01 |
description |
Background: There is currently no evidence suggesting that COVID-19 takes a different course in HIV-positive patients on antiretroviral treatment compared to the general population. However, little is known about the relation between specific HIV-related factors and the severity of the COVID-19 disease. Methods: We performed a retrospective analysis of cases collected through an on-line survey distributed by the Euroguidelines in Central and Eastern Europe Network Group. In statistical analyses characteristics of HIV-positive patients, asymptomatic/moderate and moderate/severe course were compared. Results: In total 34 HIV-positive patients diagnosed with COVID-19 were reported by 12 countries (Estonia, Czech Republic, Lithuania, Albania, Belarus, Romania, Serbia, Bosnia and Herzegovina, Poland, Russia, Hungary, Bulgaria). Asymptomatic courses of COVID-19 were reported in four (12%) cases, 11 (32%) patients presented with mild disease not requiring hospitalization, moderate disease with respiratory and/or systemic symptoms was observed in 14 (41%) cases, and severe disease with respiratory failure was found in five (15%) patients. The HIV-related characteristics of patients with an asymptomatic/mild course of COVID-19 were comparable to those with a moderate/severe course of COVID-19, except for the use of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in cART regimen (0.0% vs. 31.6% respectively, p = 0.0239). Conclusions: In our analyses HIV viral suppression and immunological status were not associated with the course of COVID-19 disease. On the contrary the cART regimen could contribute to severity of SARS-CoV-2 infection. Large and prospective studies are necessary to further investigate this relationship. |
topic |
HIV SARS-CoV-2 COVID-19 Antiretroviral therapy Protease inhibitors |
url |
http://www.sciencedirect.com/science/article/pii/S1201971220325480 |
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