Within-Network Connectivity in the Salience Network After Attention Bias Modification Training in Residual Depression: Report From a Preregistered Clinical Trial
Alterations in resting state networks (RSNs) are associated with emotional- and attentional control difficulties in depressed individuals. Attentional bias modification (ABM) training may lead to more adaptive emotional processing in depression, but little is known about the neural underpinnings ass...
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doaj-75ba3e74fab4460582da1edcbb04ad252020-11-25T02:40:24ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612018-12-011210.3389/fnhum.2018.00508429225Within-Network Connectivity in the Salience Network After Attention Bias Modification Training in Residual Depression: Report From a Preregistered Clinical TrialEva Hilland0Eva Hilland1Nils I. Landrø2Nils I. Landrø3Catherine J. Harmer4Catherine J. Harmer5Luigi A. Maglanoc6Luigi A. Maglanoc7Rune Jonassen8Rune Jonassen9Clinical Neuro-science Research Group, Department of Psychology, University of Oslo, Oslo, NorwayDivision of Psychiatry, Diakonhjemmet Hospital, Oslo, NorwayClinical Neuro-science Research Group, Department of Psychology, University of Oslo, Oslo, NorwayDivision of Psychiatry, Diakonhjemmet Hospital, Oslo, NorwayClinical Neuro-science Research Group, Department of Psychology, University of Oslo, Oslo, NorwayPsychopharmacology and Emotional Research Laboratory (PERL), Department of Psychiatry, University of Oxford, Oxford, United KingdomClinical Neuro-science Research Group, Department of Psychology, University of Oslo, Oslo, NorwayNORMENT: Norwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, NorwayClinical Neuro-science Research Group, Department of Psychology, University of Oslo, Oslo, NorwayFaculty of Health Sciences, OsloMet—Oslo Metropolitan University, Oslo, NorwayAlterations in resting state networks (RSNs) are associated with emotional- and attentional control difficulties in depressed individuals. Attentional bias modification (ABM) training may lead to more adaptive emotional processing in depression, but little is known about the neural underpinnings associated with ABM. In the current study a sample of 134 previously depressed individuals were randomized into 14 days of computerized ABM- or a closely matched placebo training regime followed by a resting state magnetic resonance imaging (MRI) scan. Using independent component analysis (ICA) we examined within-network connectivity in three major RSN’s, the default mode network (DMN), the salience network (SN) and the central executive network (CEN) after 2 weeks of ABM training. We found a significant difference between the training groups within the SN, but no difference within the DMN or CEN. Moreover, a significant symptom improvement was observed in the ABM group after training.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT02931487.https://www.frontiersin.org/article/10.3389/fnhum.2018.00508/fullindependent component analysis (ICA)salience network (SN)central executive network (CEN)default mode network (DMN)attention bias modification training (ABMT)major depression (MDD) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eva Hilland Eva Hilland Nils I. Landrø Nils I. Landrø Catherine J. Harmer Catherine J. Harmer Luigi A. Maglanoc Luigi A. Maglanoc Rune Jonassen Rune Jonassen |
spellingShingle |
Eva Hilland Eva Hilland Nils I. Landrø Nils I. Landrø Catherine J. Harmer Catherine J. Harmer Luigi A. Maglanoc Luigi A. Maglanoc Rune Jonassen Rune Jonassen Within-Network Connectivity in the Salience Network After Attention Bias Modification Training in Residual Depression: Report From a Preregistered Clinical Trial Frontiers in Human Neuroscience independent component analysis (ICA) salience network (SN) central executive network (CEN) default mode network (DMN) attention bias modification training (ABMT) major depression (MDD) |
author_facet |
Eva Hilland Eva Hilland Nils I. Landrø Nils I. Landrø Catherine J. Harmer Catherine J. Harmer Luigi A. Maglanoc Luigi A. Maglanoc Rune Jonassen Rune Jonassen |
author_sort |
Eva Hilland |
title |
Within-Network Connectivity in the Salience Network After Attention Bias Modification Training in Residual Depression: Report From a Preregistered Clinical Trial |
title_short |
Within-Network Connectivity in the Salience Network After Attention Bias Modification Training in Residual Depression: Report From a Preregistered Clinical Trial |
title_full |
Within-Network Connectivity in the Salience Network After Attention Bias Modification Training in Residual Depression: Report From a Preregistered Clinical Trial |
title_fullStr |
Within-Network Connectivity in the Salience Network After Attention Bias Modification Training in Residual Depression: Report From a Preregistered Clinical Trial |
title_full_unstemmed |
Within-Network Connectivity in the Salience Network After Attention Bias Modification Training in Residual Depression: Report From a Preregistered Clinical Trial |
title_sort |
within-network connectivity in the salience network after attention bias modification training in residual depression: report from a preregistered clinical trial |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2018-12-01 |
description |
Alterations in resting state networks (RSNs) are associated with emotional- and attentional control difficulties in depressed individuals. Attentional bias modification (ABM) training may lead to more adaptive emotional processing in depression, but little is known about the neural underpinnings associated with ABM. In the current study a sample of 134 previously depressed individuals were randomized into 14 days of computerized ABM- or a closely matched placebo training regime followed by a resting state magnetic resonance imaging (MRI) scan. Using independent component analysis (ICA) we examined within-network connectivity in three major RSN’s, the default mode network (DMN), the salience network (SN) and the central executive network (CEN) after 2 weeks of ABM training. We found a significant difference between the training groups within the SN, but no difference within the DMN or CEN. Moreover, a significant symptom improvement was observed in the ABM group after training.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT02931487. |
topic |
independent component analysis (ICA) salience network (SN) central executive network (CEN) default mode network (DMN) attention bias modification training (ABMT) major depression (MDD) |
url |
https://www.frontiersin.org/article/10.3389/fnhum.2018.00508/full |
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