Perspectives on the Combined Effects of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts in Terms of Phytochemical Profile and Pharmacological Effects
Nowadays, the tendency in pharmaceutical and food industries is to replace synthetic antioxidants with the natural ones. For this reason, there is a growing interest in analyzing natural, healthy and non-toxic additives as potential antioxidants. Some plants, which contain high levels of phenolic co...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-07-01
|
Series: | Plants |
Subjects: | |
Online Access: | https://www.mdpi.com/2223-7747/10/7/1390 |
id |
doaj-75bb153a3e3d4fbcb5c229c9da9db026 |
---|---|
record_format |
Article |
spelling |
doaj-75bb153a3e3d4fbcb5c229c9da9db0262021-07-23T14:01:48ZengMDPI AGPlants2223-77472021-07-01101390139010.3390/plants10071390Perspectives on the Combined Effects of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts in Terms of Phytochemical Profile and Pharmacological EffectsAndreea-Ina Antonescu (Mintas)0Florina Miere (Groza)1Luminita Fritea2Mariana Ganea3Mihaela Zdrinca4Luciana Dobjanschi5Angela Antonescu6Simona Ioana Vicas7Florin Bodog8Rakesh K. Sindhu9Simona Cavalu10Faculty of Medicine and Pharmacy, Doctoral School of Biomedical Science, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, RomaniaFaculty of Environmental Protection, University of Oradea, 26 Gen. Magheru Street, 410048 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, RomaniaChitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, RomaniaNowadays, the tendency in pharmaceutical and food industries is to replace synthetic antioxidants with the natural ones. For this reason, there is a growing interest in analyzing natural, healthy and non-toxic additives as potential antioxidants. Some plants, which contain high levels of phenolic compounds, present an increasing interest for medicine due to their ability to scavenge free radicals, along with other pharmacological activities, such as antibacterial activity, wound healing and anti-inflammatory effect, to mention only a few. The aim of this review is to explore the therapeutic potential of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> in relation with their phytochemical profile and to highlight the pharmacological activity of aqueous or ethanol extracts. Special attention was devoted to the dermal pathology and wound healing effects, in the context of multiple skin conditions such as acne, eczema boils, psoriasis and rashes. Additionally, both extracts (<i>Trifolium</i> sp. and <i>Ocimum</i> sp.) are characterized by high content of antioxidant compounds, which are responsible for the radiance and resistance of the skin and slowing down of the aging process by maintaining estrogen levels. Moreover, the potential combined effect of the mixed extract is pointed out in terms of future applications for wound healing, based on some preliminary results obtained from a “scratch tests” assay performed with respect to human dermal fibroblasts.https://www.mdpi.com/2223-7747/10/7/1390<i>Ocimum basilicum</i> sp.<i>Trifolium pratense</i> sp.phytochemistryantioxidant capacityantibacterial activitywound healing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andreea-Ina Antonescu (Mintas) Florina Miere (Groza) Luminita Fritea Mariana Ganea Mihaela Zdrinca Luciana Dobjanschi Angela Antonescu Simona Ioana Vicas Florin Bodog Rakesh K. Sindhu Simona Cavalu |
spellingShingle |
Andreea-Ina Antonescu (Mintas) Florina Miere (Groza) Luminita Fritea Mariana Ganea Mihaela Zdrinca Luciana Dobjanschi Angela Antonescu Simona Ioana Vicas Florin Bodog Rakesh K. Sindhu Simona Cavalu Perspectives on the Combined Effects of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts in Terms of Phytochemical Profile and Pharmacological Effects Plants <i>Ocimum basilicum</i> sp. <i>Trifolium pratense</i> sp. phytochemistry antioxidant capacity antibacterial activity wound healing |
author_facet |
Andreea-Ina Antonescu (Mintas) Florina Miere (Groza) Luminita Fritea Mariana Ganea Mihaela Zdrinca Luciana Dobjanschi Angela Antonescu Simona Ioana Vicas Florin Bodog Rakesh K. Sindhu Simona Cavalu |
author_sort |
Andreea-Ina Antonescu (Mintas) |
title |
Perspectives on the Combined Effects of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts in Terms of Phytochemical Profile and Pharmacological Effects |
title_short |
Perspectives on the Combined Effects of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts in Terms of Phytochemical Profile and Pharmacological Effects |
title_full |
Perspectives on the Combined Effects of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts in Terms of Phytochemical Profile and Pharmacological Effects |
title_fullStr |
Perspectives on the Combined Effects of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts in Terms of Phytochemical Profile and Pharmacological Effects |
title_full_unstemmed |
Perspectives on the Combined Effects of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts in Terms of Phytochemical Profile and Pharmacological Effects |
title_sort |
perspectives on the combined effects of <i>ocimum basilicum</i> and <i>trifolium pratense</i> extracts in terms of phytochemical profile and pharmacological effects |
publisher |
MDPI AG |
series |
Plants |
issn |
2223-7747 |
publishDate |
2021-07-01 |
description |
Nowadays, the tendency in pharmaceutical and food industries is to replace synthetic antioxidants with the natural ones. For this reason, there is a growing interest in analyzing natural, healthy and non-toxic additives as potential antioxidants. Some plants, which contain high levels of phenolic compounds, present an increasing interest for medicine due to their ability to scavenge free radicals, along with other pharmacological activities, such as antibacterial activity, wound healing and anti-inflammatory effect, to mention only a few. The aim of this review is to explore the therapeutic potential of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> in relation with their phytochemical profile and to highlight the pharmacological activity of aqueous or ethanol extracts. Special attention was devoted to the dermal pathology and wound healing effects, in the context of multiple skin conditions such as acne, eczema boils, psoriasis and rashes. Additionally, both extracts (<i>Trifolium</i> sp. and <i>Ocimum</i> sp.) are characterized by high content of antioxidant compounds, which are responsible for the radiance and resistance of the skin and slowing down of the aging process by maintaining estrogen levels. Moreover, the potential combined effect of the mixed extract is pointed out in terms of future applications for wound healing, based on some preliminary results obtained from a “scratch tests” assay performed with respect to human dermal fibroblasts. |
topic |
<i>Ocimum basilicum</i> sp. <i>Trifolium pratense</i> sp. phytochemistry antioxidant capacity antibacterial activity wound healing |
url |
https://www.mdpi.com/2223-7747/10/7/1390 |
work_keys_str_mv |
AT andreeainaantonescumintas perspectivesonthecombinedeffectsofiocimumbasilicumianditrifoliumpratenseiextractsintermsofphytochemicalprofileandpharmacologicaleffects AT florinamieregroza perspectivesonthecombinedeffectsofiocimumbasilicumianditrifoliumpratenseiextractsintermsofphytochemicalprofileandpharmacologicaleffects AT luminitafritea perspectivesonthecombinedeffectsofiocimumbasilicumianditrifoliumpratenseiextractsintermsofphytochemicalprofileandpharmacologicaleffects AT marianaganea perspectivesonthecombinedeffectsofiocimumbasilicumianditrifoliumpratenseiextractsintermsofphytochemicalprofileandpharmacologicaleffects AT mihaelazdrinca perspectivesonthecombinedeffectsofiocimumbasilicumianditrifoliumpratenseiextractsintermsofphytochemicalprofileandpharmacologicaleffects AT lucianadobjanschi perspectivesonthecombinedeffectsofiocimumbasilicumianditrifoliumpratenseiextractsintermsofphytochemicalprofileandpharmacologicaleffects AT angelaantonescu perspectivesonthecombinedeffectsofiocimumbasilicumianditrifoliumpratenseiextractsintermsofphytochemicalprofileandpharmacologicaleffects AT simonaioanavicas perspectivesonthecombinedeffectsofiocimumbasilicumianditrifoliumpratenseiextractsintermsofphytochemicalprofileandpharmacologicaleffects AT florinbodog perspectivesonthecombinedeffectsofiocimumbasilicumianditrifoliumpratenseiextractsintermsofphytochemicalprofileandpharmacologicaleffects AT rakeshksindhu perspectivesonthecombinedeffectsofiocimumbasilicumianditrifoliumpratenseiextractsintermsofphytochemicalprofileandpharmacologicaleffects AT simonacavalu perspectivesonthecombinedeffectsofiocimumbasilicumianditrifoliumpratenseiextractsintermsofphytochemicalprofileandpharmacologicaleffects |
_version_ |
1721286323709411328 |