<sup>18</sup>F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy
Tertiary hyperparathyroidism (HPT) is a metabolic disorder characterized by the semi-autonomous hypersecretion of parathyroid hormone (PTH), leading to hypercalcemia. It can be the end result of persistent secondary hyperparathyroidism and is most commonly observed in patients with long-standing chr...
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doaj-75c10b7c2c5943d88a4f0b191524ea4f2020-11-25T03:57:09ZengMDPI AGDiagnostics2075-44182020-10-011085185110.3390/diagnostics10100851<sup>18</sup>F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal OsteodystrophyCristina Ferrari0Valentina Lavelli1Giulia Santo2Maria Teresa Frugis3Francesca Iuele4Giuseppe Rubini5Angela Sardaro6Nuclear Medicine Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyNuclear Medicine Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyNuclear Medicine Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyNuclear Medicine Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyNuclear Medicine Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyNuclear Medicine Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalySection of Radiology and Radiation Oncology, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyTertiary hyperparathyroidism (HPT) is a metabolic disorder characterized by the semi-autonomous hypersecretion of parathyroid hormone (PTH), leading to hypercalcemia. It can be the end result of persistent secondary hyperparathyroidism and is most commonly observed in patients with long-standing chronic kidney disease (CKD) and often after renal transplantation. Untreated HPT can lead to progressive bone disease, fibrocystic osteitis, and soft-tissue calcifications, along with other severe complications. In the 2009 Kidney Disease Improving Global Outcomes (KDIGO) guidelines, CKD-Mineral and Bone Disorder (CKD-MBD) is used to describe the broader clinical syndrome encompassing mineral, bone, and calcific cardiovascular abnormalities that develop as a complication of CKD. We report a 62-year-old female with a severe HPT evolved from advanced chronic kidney disease (stage 5D, KDIGO). Patient was evaluated with multimodality nuclear medicine functional imaging to assess hyperfunctioning parathyroid glands and bone lesions. Tc-99m-methoxyisobutylisonitrile (MIBI) dual-phase scintigraphy, Tc-99m-methylenediphosphonate (MDP) bone scan and <sup>18</sup>F-Fluorocholine positron emission tomography/computed tomography (<sup>18</sup>F-FCH PET/CT) were performed before surgery.https://www.mdpi.com/2075-4418/10/10/851tertiary hyperparathyroidismrenal osteodystrophydual-phase Tc-99m-MIBI<sup>18</sup>F-fluorocholinepositron emission tomography/computed tomographyTc-99m-MDP |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cristina Ferrari Valentina Lavelli Giulia Santo Maria Teresa Frugis Francesca Iuele Giuseppe Rubini Angela Sardaro |
spellingShingle |
Cristina Ferrari Valentina Lavelli Giulia Santo Maria Teresa Frugis Francesca Iuele Giuseppe Rubini Angela Sardaro <sup>18</sup>F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy Diagnostics tertiary hyperparathyroidism renal osteodystrophy dual-phase Tc-99m-MIBI <sup>18</sup>F-fluorocholine positron emission tomography/computed tomography Tc-99m-MDP |
author_facet |
Cristina Ferrari Valentina Lavelli Giulia Santo Maria Teresa Frugis Francesca Iuele Giuseppe Rubini Angela Sardaro |
author_sort |
Cristina Ferrari |
title |
<sup>18</sup>F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy |
title_short |
<sup>18</sup>F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy |
title_full |
<sup>18</sup>F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy |
title_fullStr |
<sup>18</sup>F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy |
title_full_unstemmed |
<sup>18</sup>F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy |
title_sort |
<sup>18</sup>f-fluorocholine pet/ct, tc-99m-mibi and tc-99m-mdp spect/ct in tertiary hyperparathyroidism with renal osteodystrophy |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-10-01 |
description |
Tertiary hyperparathyroidism (HPT) is a metabolic disorder characterized by the semi-autonomous hypersecretion of parathyroid hormone (PTH), leading to hypercalcemia. It can be the end result of persistent secondary hyperparathyroidism and is most commonly observed in patients with long-standing chronic kidney disease (CKD) and often after renal transplantation. Untreated HPT can lead to progressive bone disease, fibrocystic osteitis, and soft-tissue calcifications, along with other severe complications. In the 2009 Kidney Disease Improving Global Outcomes (KDIGO) guidelines, CKD-Mineral and Bone Disorder (CKD-MBD) is used to describe the broader clinical syndrome encompassing mineral, bone, and calcific cardiovascular abnormalities that develop as a complication of CKD. We report a 62-year-old female with a severe HPT evolved from advanced chronic kidney disease (stage 5D, KDIGO). Patient was evaluated with multimodality nuclear medicine functional imaging to assess hyperfunctioning parathyroid glands and bone lesions. Tc-99m-methoxyisobutylisonitrile (MIBI) dual-phase scintigraphy, Tc-99m-methylenediphosphonate (MDP) bone scan and <sup>18</sup>F-Fluorocholine positron emission tomography/computed tomography (<sup>18</sup>F-FCH PET/CT) were performed before surgery. |
topic |
tertiary hyperparathyroidism renal osteodystrophy dual-phase Tc-99m-MIBI <sup>18</sup>F-fluorocholine positron emission tomography/computed tomography Tc-99m-MDP |
url |
https://www.mdpi.com/2075-4418/10/10/851 |
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