Insomnia and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis
Aim: This sudy aims to investigate the association between insomnia or excessive daytime sleepiness (EDS) and risk of nonalcoholic fatty liver disease (NAFLD). Methods: We searched published studies indexed in MEDLINE and EMBASE database from inception to December 2015. Studies that reported odds ra...
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Wolters Kluwer Medknow Publications
2017-01-01
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doaj-75cbcef4e37c448eb3573e93b9b085bb2020-11-24T22:30:06ZengWolters Kluwer Medknow PublicationsJournal of Postgraduate Medicine0022-38590972-28232017-01-0163422623110.4103/jpgm.JPGM_140_17Insomnia and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysisK WijarnpreechaC ThongprayoonP PanjawatananP UngprasertAim: This sudy aims to investigate the association between insomnia or excessive daytime sleepiness (EDS) and risk of nonalcoholic fatty liver disease (NAFLD). Methods: We searched published studies indexed in MEDLINE and EMBASE database from inception to December 2015. Studies that reported odds ratios (ORs), risk ratios, hazard ratios or standardized incidence ratio with 95% confidence intervals (CI) comparing the risk of NAFLD among participants who had insomnia or EDS versus those without insomnia or EDS were included. Pooled ORs and 95% CI were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Cochran's Q test and I2 statistic were used to determine the between-study heterogeneity. Results: Our search strategy yielded 2117 potentially relevant articles (781 articles from MEDLINE and 1336 articles from EMBASE). After comprehensive review, seven studies (three cross-sectional studies and four case–control studies) were found to be eligible and were included in the meta-analysis. The risk of NAFLD in participants who had insomnia was significantly higher with the pooled OR of 1.13 (95% CI, 1.00–1.27). The statistical heterogeneity was moderate with an I2 of 62%. Elevated risk of NAFLD was also observed among participants with EDS even though the 95% CI was wider and did not reach statistical significance (pooled OR 2.21; 95% CI, 0.84–5.82). The statistical heterogeneity was moderate with an I2 of 62%. Conclusions: Our study demonstrated an increased risk of NAFLD among participants who had insomnia or EDS. Whether this association is causal needs further investigations.http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2017;volume=63;issue=4;spage=226;epage=231;aulast=WijarnpreechaInsomniameta.analysisnonalcoholic fatty liver diseasenonalcoholic steatohepatitissleep quality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
K Wijarnpreecha C Thongprayoon P Panjawatanan P Ungprasert |
spellingShingle |
K Wijarnpreecha C Thongprayoon P Panjawatanan P Ungprasert Insomnia and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis Journal of Postgraduate Medicine Insomnia meta.analysis nonalcoholic fatty liver disease nonalcoholic steatohepatitis sleep quality |
author_facet |
K Wijarnpreecha C Thongprayoon P Panjawatanan P Ungprasert |
author_sort |
K Wijarnpreecha |
title |
Insomnia and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis |
title_short |
Insomnia and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis |
title_full |
Insomnia and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis |
title_fullStr |
Insomnia and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis |
title_full_unstemmed |
Insomnia and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis |
title_sort |
insomnia and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Postgraduate Medicine |
issn |
0022-3859 0972-2823 |
publishDate |
2017-01-01 |
description |
Aim: This sudy aims to investigate the association between insomnia or excessive daytime sleepiness (EDS) and risk of nonalcoholic fatty liver disease (NAFLD). Methods: We searched published studies indexed in MEDLINE and EMBASE database from inception to December 2015. Studies that reported odds ratios (ORs), risk ratios, hazard ratios or standardized incidence ratio with 95% confidence intervals (CI) comparing the risk of NAFLD among participants who had insomnia or EDS versus those without insomnia or EDS were included. Pooled ORs and 95% CI were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Cochran's Q test and I2 statistic were used to determine the between-study heterogeneity. Results: Our search strategy yielded 2117 potentially relevant articles (781 articles from MEDLINE and 1336 articles from EMBASE). After comprehensive review, seven studies (three cross-sectional studies and four case–control studies) were found to be eligible and were included in the meta-analysis. The risk of NAFLD in participants who had insomnia was significantly higher with the pooled OR of 1.13 (95% CI, 1.00–1.27). The statistical heterogeneity was moderate with an I2 of 62%. Elevated risk of NAFLD was also observed among participants with EDS even though the 95% CI was wider and did not reach statistical significance (pooled OR 2.21; 95% CI, 0.84–5.82). The statistical heterogeneity was moderate with an I2 of 62%. Conclusions: Our study demonstrated an increased risk of NAFLD among participants who had insomnia or EDS. Whether this association is causal needs further investigations. |
topic |
Insomnia meta.analysis nonalcoholic fatty liver disease nonalcoholic steatohepatitis sleep quality |
url |
http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2017;volume=63;issue=4;spage=226;epage=231;aulast=Wijarnpreecha |
work_keys_str_mv |
AT kwijarnpreecha insomniaandriskofnonalcoholicfattyliverdiseaseasystematicreviewandmetaanalysis AT cthongprayoon insomniaandriskofnonalcoholicfattyliverdiseaseasystematicreviewandmetaanalysis AT ppanjawatanan insomniaandriskofnonalcoholicfattyliverdiseaseasystematicreviewandmetaanalysis AT pungprasert insomniaandriskofnonalcoholicfattyliverdiseaseasystematicreviewandmetaanalysis |
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1725741971759169536 |