Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles
Nanoparticles are considered to be a powerful approach for the delivery of poorly water-soluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable method, the flash nanoprecipitation (FNP) has been widely used...
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doaj-75cbcf80330a4707b31e5ed8d270f9092020-11-25T01:13:37ZengElsevierActa Pharmaceutica Sinica B2211-38352019-01-0191418Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticlesJinsong Tao0Shing Fung Chow1Ying Zheng2State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macau, ChinaDepartment of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macau, China; Corresponding author. Tel.: +853 88224687; fax: +853 28841358.Nanoparticles are considered to be a powerful approach for the delivery of poorly water-soluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable method, the flash nanoprecipitation (FNP) has been widely used to fabricate these drug nanoparticles, including pure drug nanocrystals, polymeric micelles, polymeric nanoparticles, solid lipid nanoparticles, and polyelectrolyte complexes. This review introduces the application of FNP to produce poorly water-soluble drug nanoparticles by controllable mixing devices, such as confined impinging jets mixer (CIJM), multi-inlet vortex mixer (MIVM) and many other microfluidic mixer systems. The formation mechanisms and processes of drug nanoparticles by FNP are described in detail. Then, the controlling of supersaturation level and mixing rate during the FNP process to tailor the ultrafine drug nanoparticles as well as the influence of drugs, solvent, anti-solvent, stabilizers and temperature on the fabrication are discussed. The ultrafine and uniform nanoparticles of poorly water-soluble drug nanoparticles prepared by CIJM, MIVM and microfluidic mixer systems are reviewed briefly. We believe that the application of microfluidic mixing devices in laboratory with continuous process control and good reproducibility will be benefit for industrial formulation scale-up. KEY WORDS: Poorly water-soluble drug, Flash nanoprecipitation, Microfluidic mixer device, Nanoparticleshttp://www.sciencedirect.com/science/article/pii/S2211383518306130 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinsong Tao Shing Fung Chow Ying Zheng |
spellingShingle |
Jinsong Tao Shing Fung Chow Ying Zheng Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles Acta Pharmaceutica Sinica B |
author_facet |
Jinsong Tao Shing Fung Chow Ying Zheng |
author_sort |
Jinsong Tao |
title |
Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles |
title_short |
Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles |
title_full |
Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles |
title_fullStr |
Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles |
title_full_unstemmed |
Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles |
title_sort |
application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles |
publisher |
Elsevier |
series |
Acta Pharmaceutica Sinica B |
issn |
2211-3835 |
publishDate |
2019-01-01 |
description |
Nanoparticles are considered to be a powerful approach for the delivery of poorly water-soluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable method, the flash nanoprecipitation (FNP) has been widely used to fabricate these drug nanoparticles, including pure drug nanocrystals, polymeric micelles, polymeric nanoparticles, solid lipid nanoparticles, and polyelectrolyte complexes. This review introduces the application of FNP to produce poorly water-soluble drug nanoparticles by controllable mixing devices, such as confined impinging jets mixer (CIJM), multi-inlet vortex mixer (MIVM) and many other microfluidic mixer systems. The formation mechanisms and processes of drug nanoparticles by FNP are described in detail. Then, the controlling of supersaturation level and mixing rate during the FNP process to tailor the ultrafine drug nanoparticles as well as the influence of drugs, solvent, anti-solvent, stabilizers and temperature on the fabrication are discussed. The ultrafine and uniform nanoparticles of poorly water-soluble drug nanoparticles prepared by CIJM, MIVM and microfluidic mixer systems are reviewed briefly. We believe that the application of microfluidic mixing devices in laboratory with continuous process control and good reproducibility will be benefit for industrial formulation scale-up. KEY WORDS: Poorly water-soluble drug, Flash nanoprecipitation, Microfluidic mixer device, Nanoparticles |
url |
http://www.sciencedirect.com/science/article/pii/S2211383518306130 |
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