An Antimicrobial Compound Isolated from Cinnamomum Iners Leaves with Activity against Methicillin-Resistant Staphylococcus Aureus
This study was designed to investigate the antimicrobial activity of Cinnamomum iners standardized leave methanolic extract (CSLE), its fractions and isolated compounds. CSLE and fractions were subjected to disc diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration...
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2011-04-01
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doaj-75cf5bf1578547559950125601dd112f2020-11-25T01:16:13ZengMDPI AGMolecules1420-30492011-04-011643037304710.3390/molecules16043037An Antimicrobial Compound Isolated from Cinnamomum Iners Leaves with Activity against Methicillin-Resistant Staphylococcus AureusSharif Mahsufi MansorMarina ShahSabariah IsmailJayant IndurkarFazlina MustaffaThis study was designed to investigate the antimicrobial activity of Cinnamomum iners standardized leave methanolic extract (CSLE), its fractions and isolated compounds. CSLE and fractions were subjected to disc diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests using different Gram positive and Gram negative bacteria and yeast. Within the series of fractions tested, the ethyl acetate fraction was the most active, particularly against methicillin resistant Staphylococcus aureus (MRSA) and Escherichia coli, with MIC values of 100 and 200 µg/mL, respectively. The active compound in this fraction was isolated and identified as xanthorrhizol [5-(1, 5-dimethyl-4-hexenyl)-2-methylphenol] by various spectroscopic techniques. The overall results of this study provide evidence that Cinnamomum iners leaves extract as well as the isolated compound xanthorrhizol exhibit antimicrobial activity for both Gram negative and Gram positive pathogens, especially against MRSA strains. http://www.mdpi.com/1420-3049/16/4/3037/Cinnamomum inersantimicrobial activityxanthorrhizol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sharif Mahsufi Mansor Marina Shah Sabariah Ismail Jayant Indurkar Fazlina Mustaffa |
spellingShingle |
Sharif Mahsufi Mansor Marina Shah Sabariah Ismail Jayant Indurkar Fazlina Mustaffa An Antimicrobial Compound Isolated from Cinnamomum Iners Leaves with Activity against Methicillin-Resistant Staphylococcus Aureus Molecules Cinnamomum iners antimicrobial activity xanthorrhizol |
author_facet |
Sharif Mahsufi Mansor Marina Shah Sabariah Ismail Jayant Indurkar Fazlina Mustaffa |
author_sort |
Sharif Mahsufi Mansor |
title |
An Antimicrobial Compound Isolated from Cinnamomum Iners Leaves with Activity against Methicillin-Resistant Staphylococcus Aureus |
title_short |
An Antimicrobial Compound Isolated from Cinnamomum Iners Leaves with Activity against Methicillin-Resistant Staphylococcus Aureus |
title_full |
An Antimicrobial Compound Isolated from Cinnamomum Iners Leaves with Activity against Methicillin-Resistant Staphylococcus Aureus |
title_fullStr |
An Antimicrobial Compound Isolated from Cinnamomum Iners Leaves with Activity against Methicillin-Resistant Staphylococcus Aureus |
title_full_unstemmed |
An Antimicrobial Compound Isolated from Cinnamomum Iners Leaves with Activity against Methicillin-Resistant Staphylococcus Aureus |
title_sort |
antimicrobial compound isolated from cinnamomum iners leaves with activity against methicillin-resistant staphylococcus aureus |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2011-04-01 |
description |
This study was designed to investigate the antimicrobial activity of Cinnamomum iners standardized leave methanolic extract (CSLE), its fractions and isolated compounds. CSLE and fractions were subjected to disc diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests using different Gram positive and Gram negative bacteria and yeast. Within the series of fractions tested, the ethyl acetate fraction was the most active, particularly against methicillin resistant Staphylococcus aureus (MRSA) and Escherichia coli, with MIC values of 100 and 200 µg/mL, respectively. The active compound in this fraction was isolated and identified as xanthorrhizol [5-(1, 5-dimethyl-4-hexenyl)-2-methylphenol] by various spectroscopic techniques. The overall results of this study provide evidence that Cinnamomum iners leaves extract as well as the isolated compound xanthorrhizol exhibit antimicrobial activity for both Gram negative and Gram positive pathogens, especially against MRSA strains. |
topic |
Cinnamomum iners antimicrobial activity xanthorrhizol |
url |
http://www.mdpi.com/1420-3049/16/4/3037/ |
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