Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review
Abstract Objective The etiology of major depressive disorder (MDD) is multi‐factorial and has been associated with a perturbed gut microbiota. Thus, it is therefore of great importance to determine any variations in gut microbiota in patients with MDD. Methods A systematic literature search was cond...
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doaj-75e77079086941adaaf6777bc3ff3d2e2021-07-30T08:47:51ZengWileyBrain and Behavior2162-32792021-07-01117n/an/a10.1002/brb3.2177Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic reviewJulie Kristine Knudsen0Caspar Bundgaard‐Nielsen1Simon Hjerrild2René Ernst Nielsen3Peter Leutscher4Suzette Sørensen5Centre for Clinical Research North Denmark Regional HospitalHjoerring DenmarkCentre for Clinical Research North Denmark Regional HospitalHjoerring DenmarkPsychosis Research Unit Aarhus University HospitalAarhus DenmarkDepartment of Clinical Medicine Aalborg UniversityAalborg DenmarkCentre for Clinical Research North Denmark Regional HospitalHjoerring DenmarkCentre for Clinical Research North Denmark Regional HospitalHjoerring DenmarkAbstract Objective The etiology of major depressive disorder (MDD) is multi‐factorial and has been associated with a perturbed gut microbiota. Thus, it is therefore of great importance to determine any variations in gut microbiota in patients with MDD. Methods A systematic literature search was conducted including original research articles based on gut microbiota studies performed in patients with MDD. Demographic and clinical characteristics, applied methodology and observed gut microbiota composition were compared between included studies. Results Seventeen studies were included with a total of 738 patients with MDD and 782 healthy controls using different DNA purification methods, sequencing platforms and data analysis models. Four studies found a reduced α‐diversity in patients with MDD, while gut microbiota compositions clustered separately according to β‐diversity between patients and controls in twelve studies. Additionally, there was an increase in relative abundance of Eggerthella, Atopobium, and Bifidobacterium and a decreased relative abundance of Faecalibacterium in patients with MDD compared with healthy controls. Conclusion Gut microbiota differs significantly when comparing patients with MDD and healthy controls, though inconsistently across studies. The heterogeneity in gut microbiota compositions between the studies may be explained by variations in study design.https://doi.org/10.1002/brb3.2177depressiongut‐brain axismajor depressive disordermicrobiomemicrobiotaunipolar depression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julie Kristine Knudsen Caspar Bundgaard‐Nielsen Simon Hjerrild René Ernst Nielsen Peter Leutscher Suzette Sørensen |
spellingShingle |
Julie Kristine Knudsen Caspar Bundgaard‐Nielsen Simon Hjerrild René Ernst Nielsen Peter Leutscher Suzette Sørensen Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review Brain and Behavior depression gut‐brain axis major depressive disorder microbiome microbiota unipolar depression |
author_facet |
Julie Kristine Knudsen Caspar Bundgaard‐Nielsen Simon Hjerrild René Ernst Nielsen Peter Leutscher Suzette Sørensen |
author_sort |
Julie Kristine Knudsen |
title |
Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review |
title_short |
Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review |
title_full |
Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review |
title_fullStr |
Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review |
title_full_unstemmed |
Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review |
title_sort |
gut microbiota variations in patients diagnosed with major depressive disorder—a systematic review |
publisher |
Wiley |
series |
Brain and Behavior |
issn |
2162-3279 |
publishDate |
2021-07-01 |
description |
Abstract Objective The etiology of major depressive disorder (MDD) is multi‐factorial and has been associated with a perturbed gut microbiota. Thus, it is therefore of great importance to determine any variations in gut microbiota in patients with MDD. Methods A systematic literature search was conducted including original research articles based on gut microbiota studies performed in patients with MDD. Demographic and clinical characteristics, applied methodology and observed gut microbiota composition were compared between included studies. Results Seventeen studies were included with a total of 738 patients with MDD and 782 healthy controls using different DNA purification methods, sequencing platforms and data analysis models. Four studies found a reduced α‐diversity in patients with MDD, while gut microbiota compositions clustered separately according to β‐diversity between patients and controls in twelve studies. Additionally, there was an increase in relative abundance of Eggerthella, Atopobium, and Bifidobacterium and a decreased relative abundance of Faecalibacterium in patients with MDD compared with healthy controls. Conclusion Gut microbiota differs significantly when comparing patients with MDD and healthy controls, though inconsistently across studies. The heterogeneity in gut microbiota compositions between the studies may be explained by variations in study design. |
topic |
depression gut‐brain axis major depressive disorder microbiome microbiota unipolar depression |
url |
https://doi.org/10.1002/brb3.2177 |
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