Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite
The preparation, characterization, and in vitro release of 5-aminosalicylic acid (5-ASA)from methacrylic acid (MAA)/perlite composites (APC) prepared via a sol–gel route are reported. The free-radical graft polymerization of methacrylic acid (MAA) onto perlite particles was studied experimentally. T...
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doaj-75eeef2daa09445d86484ae1836adfb82020-11-24T23:55:16ZengMDPI AGInternational Journal of Molecular Sciences1422-00672010-04-011141546155610.3390/ijms11041546Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite CompositeMehrdad MahkamLaleh VakhshouriThe preparation, characterization, and in vitro release of 5-aminosalicylic acid (5-ASA)from methacrylic acid (MAA)/perlite composites (APC) prepared via a sol–gel route are reported. The free-radical graft polymerization of methacrylic acid (MAA) onto perlite particles was studied experimentally. The grafting procedure consisted of surface activation with 3-(trimethoxysilyl) propyl methacrylate (TSPA), followed by free-radical graft polymerization of methacrylic acid (MAA) in ethyl acetate with 2,2΄-azobis-isobutyronitrile (AIBN) initiator. The composition of the composites hybrid materials was determined by FTIR spectroscopy. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). The dried composites were immersed in a saturated solution of 5-ASA in water overnight and dried over a period of three days at room temperature and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4). The 5-ASA concentration of the solution was measured using a UV-Vis spectrophotometer (205 nm) at different time intervals. The in vitro drug release test revealed that the release rate of 5-ASA in buffer solutions increased with the silica content in the composites; on the contrary, the increase of the content of 3-(trimethoxysilyl)propyl methacrylate (TSPA), a coupling agent, decreased the drug release rate. http://www.mdpi.com/1422-0067/11/4/1546/methacrylic acidperlitesilylationpolymerizationpolymer grafting |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehrdad Mahkam Laleh Vakhshouri |
spellingShingle |
Mehrdad Mahkam Laleh Vakhshouri Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite International Journal of Molecular Sciences methacrylic acid perlite silylation polymerization polymer grafting |
author_facet |
Mehrdad Mahkam Laleh Vakhshouri |
author_sort |
Mehrdad Mahkam |
title |
Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite |
title_short |
Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite |
title_full |
Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite |
title_fullStr |
Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite |
title_full_unstemmed |
Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite |
title_sort |
colon-specific drug delivery behavior of ph-responsive pmaa/perlite composite |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2010-04-01 |
description |
The preparation, characterization, and in vitro release of 5-aminosalicylic acid (5-ASA)from methacrylic acid (MAA)/perlite composites (APC) prepared via a sol–gel route are reported. The free-radical graft polymerization of methacrylic acid (MAA) onto perlite particles was studied experimentally. The grafting procedure consisted of surface activation with 3-(trimethoxysilyl) propyl methacrylate (TSPA), followed by free-radical graft polymerization of methacrylic acid (MAA) in ethyl acetate with 2,2΄-azobis-isobutyronitrile (AIBN) initiator. The composition of the composites hybrid materials was determined by FTIR spectroscopy. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). The dried composites were immersed in a saturated solution of 5-ASA in water overnight and dried over a period of three days at room temperature and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4). The 5-ASA concentration of the solution was measured using a UV-Vis spectrophotometer (205 nm) at different time intervals. The in vitro drug release test revealed that the release rate of 5-ASA in buffer solutions increased with the silica content in the composites; on the contrary, the increase of the content of 3-(trimethoxysilyl)propyl methacrylate (TSPA), a coupling agent, decreased the drug release rate. |
topic |
methacrylic acid perlite silylation polymerization polymer grafting |
url |
http://www.mdpi.com/1422-0067/11/4/1546/ |
work_keys_str_mv |
AT mehrdadmahkam colonspecificdrugdeliverybehaviorofphresponsivepmaaperlitecomposite AT lalehvakhshouri colonspecificdrugdeliverybehaviorofphresponsivepmaaperlitecomposite |
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