Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma.
Cannabinoid receptor 1 (CB1) is expressed in certain types of malignancies. An analysis of CB1 expression and function in Hodgkin lymphoma (HL), one of the most frequent lymphomas, was not performed to date.We examined the distribution of CB1 protein in primary cases of HL. Using lymphoma derived ce...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3857220?pdf=render |
id |
doaj-75f4d2e90ae74646ae25c0d5991e3f8b |
---|---|
record_format |
Article |
spelling |
doaj-75f4d2e90ae74646ae25c0d5991e3f8b2020-11-24T21:44:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8167510.1371/journal.pone.0081675Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma.Alexander H BenzChristoph RennéErik MarondeMarco KochUrszula GrabiecSonja KallendruschBenjamin RengstlSebastian NewrzelaSylvia HartmannMartin-Leo HansmannFaramarz DehghaniCannabinoid receptor 1 (CB1) is expressed in certain types of malignancies. An analysis of CB1 expression and function in Hodgkin lymphoma (HL), one of the most frequent lymphomas, was not performed to date.We examined the distribution of CB1 protein in primary cases of HL. Using lymphoma derived cell lines, the role of CB1 signaling on cell survival was investigated.A predominant expression of CB1 was found in Hodgkin-Reed-Sternberg cells in a vast majority of classical HL cases. The HL cell lines L428, L540 and KM-H2 showed strong CB1-abundance and displayed a dose-dependent decline of viability under CB1 inhibition with AM251. Further, application of AM251 led to decrease of constitutively active NFκB/p65, a crucial survival factor of HRS-cells, and was followed by elevation of apoptotic markers in HL cells.The present study identifies CB1 as a feature of HL, which might serve as a potential selective target in the treatment of Hodgkin lymphoma.http://europepmc.org/articles/PMC3857220?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexander H Benz Christoph Renné Erik Maronde Marco Koch Urszula Grabiec Sonja Kallendrusch Benjamin Rengstl Sebastian Newrzela Sylvia Hartmann Martin-Leo Hansmann Faramarz Dehghani |
spellingShingle |
Alexander H Benz Christoph Renné Erik Maronde Marco Koch Urszula Grabiec Sonja Kallendrusch Benjamin Rengstl Sebastian Newrzela Sylvia Hartmann Martin-Leo Hansmann Faramarz Dehghani Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. PLoS ONE |
author_facet |
Alexander H Benz Christoph Renné Erik Maronde Marco Koch Urszula Grabiec Sonja Kallendrusch Benjamin Rengstl Sebastian Newrzela Sylvia Hartmann Martin-Leo Hansmann Faramarz Dehghani |
author_sort |
Alexander H Benz |
title |
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. |
title_short |
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. |
title_full |
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. |
title_fullStr |
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. |
title_full_unstemmed |
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. |
title_sort |
expression and functional relevance of cannabinoid receptor 1 in hodgkin lymphoma. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Cannabinoid receptor 1 (CB1) is expressed in certain types of malignancies. An analysis of CB1 expression and function in Hodgkin lymphoma (HL), one of the most frequent lymphomas, was not performed to date.We examined the distribution of CB1 protein in primary cases of HL. Using lymphoma derived cell lines, the role of CB1 signaling on cell survival was investigated.A predominant expression of CB1 was found in Hodgkin-Reed-Sternberg cells in a vast majority of classical HL cases. The HL cell lines L428, L540 and KM-H2 showed strong CB1-abundance and displayed a dose-dependent decline of viability under CB1 inhibition with AM251. Further, application of AM251 led to decrease of constitutively active NFκB/p65, a crucial survival factor of HRS-cells, and was followed by elevation of apoptotic markers in HL cells.The present study identifies CB1 as a feature of HL, which might serve as a potential selective target in the treatment of Hodgkin lymphoma. |
url |
http://europepmc.org/articles/PMC3857220?pdf=render |
work_keys_str_mv |
AT alexanderhbenz expressionandfunctionalrelevanceofcannabinoidreceptor1inhodgkinlymphoma AT christophrenne expressionandfunctionalrelevanceofcannabinoidreceptor1inhodgkinlymphoma AT erikmaronde expressionandfunctionalrelevanceofcannabinoidreceptor1inhodgkinlymphoma AT marcokoch expressionandfunctionalrelevanceofcannabinoidreceptor1inhodgkinlymphoma AT urszulagrabiec expressionandfunctionalrelevanceofcannabinoidreceptor1inhodgkinlymphoma AT sonjakallendrusch expressionandfunctionalrelevanceofcannabinoidreceptor1inhodgkinlymphoma AT benjaminrengstl expressionandfunctionalrelevanceofcannabinoidreceptor1inhodgkinlymphoma AT sebastiannewrzela expressionandfunctionalrelevanceofcannabinoidreceptor1inhodgkinlymphoma AT sylviahartmann expressionandfunctionalrelevanceofcannabinoidreceptor1inhodgkinlymphoma AT martinleohansmann expressionandfunctionalrelevanceofcannabinoidreceptor1inhodgkinlymphoma AT faramarzdehghani expressionandfunctionalrelevanceofcannabinoidreceptor1inhodgkinlymphoma |
_version_ |
1725911023536308224 |