LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancers
Abstract Long non-coding RNAs (lncRNAs) represent an important class of RNAs comprising more than 200 nucleotides, which are produced by RNA polymerase II. Although lacking an open reading framework and protein-encoding activity, lncRNAs can mediate endogenous gene expression by serving as chromatin...
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doaj-75f525fab2e64dfb9833333445195e2f2020-11-25T03:31:03ZengBMCBiomarker Research2050-77712020-09-018111110.1186/s40364-020-00221-4LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancersYuhang Xiao0Ta Xiao1Wei Ou2Zhining Wu3Jie Wu4Jinming Tang5Bo Tian6Yong Zhou7Min Su8Wenxiang Wang9Thoracic Surgery Department 2, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityInstitute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of Pharmacy, The First People’s Hospital of Yue YangThoracic Surgery Department 2, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityThoracic Surgery Department 2, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityThoracic Surgery Department 2, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityThoracic Surgery Department 2, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityThoracic Surgery Department 2, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityThoracic Surgery Department 2, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityThoracic Surgery Department 2, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityAbstract Long non-coding RNAs (lncRNAs) represent an important class of RNAs comprising more than 200 nucleotides, which are produced by RNA polymerase II. Although lacking an open reading framework and protein-encoding activity, lncRNAs can mediate endogenous gene expression by serving as chromatin remodeler, transcriptional or post-transcriptional modulator, and splicing regulator during gene modification. In recent years, increasing evidence shows the significance of lncRNAs in many malignancies, with vital roles in tumorigenesis and cancer progression. Moreover, lncRNAs were also considered potential diagnostic and prognostic markers in cancer. The lncRNA small nuclear RNA host gene 16 (SNHG16), found on chromosome 17q25.1, represents a novel tumor-associated lncRNA. SNHG16 was recently found to exhibit dysregulated expression in a variety of malignancies. There are growing evidence of SNHG16’s involvement in characteristics of cancer, including proliferation, apoptosis, together with its involvement in chemoresistance. In addition, SNHG16 has been described as a promising diagnostic and prognostic biomarker in cancer patients. The current review briefly summarizes recently reported findings about SNHG16 and discuss its expression, roles, mechanisms, and diagnostic and prognostic values in human cancers.http://link.springer.com/article/10.1186/s40364-020-00221-4SNHG16Long non-coding RNAHuman cancerMechanismBiomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuhang Xiao Ta Xiao Wei Ou Zhining Wu Jie Wu Jinming Tang Bo Tian Yong Zhou Min Su Wenxiang Wang |
spellingShingle |
Yuhang Xiao Ta Xiao Wei Ou Zhining Wu Jie Wu Jinming Tang Bo Tian Yong Zhou Min Su Wenxiang Wang LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancers Biomarker Research SNHG16 Long non-coding RNA Human cancer Mechanism Biomarker |
author_facet |
Yuhang Xiao Ta Xiao Wei Ou Zhining Wu Jie Wu Jinming Tang Bo Tian Yong Zhou Min Su Wenxiang Wang |
author_sort |
Yuhang Xiao |
title |
LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancers |
title_short |
LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancers |
title_full |
LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancers |
title_fullStr |
LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancers |
title_full_unstemmed |
LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancers |
title_sort |
lncrna snhg16 as a potential biomarker and therapeutic target in human cancers |
publisher |
BMC |
series |
Biomarker Research |
issn |
2050-7771 |
publishDate |
2020-09-01 |
description |
Abstract Long non-coding RNAs (lncRNAs) represent an important class of RNAs comprising more than 200 nucleotides, which are produced by RNA polymerase II. Although lacking an open reading framework and protein-encoding activity, lncRNAs can mediate endogenous gene expression by serving as chromatin remodeler, transcriptional or post-transcriptional modulator, and splicing regulator during gene modification. In recent years, increasing evidence shows the significance of lncRNAs in many malignancies, with vital roles in tumorigenesis and cancer progression. Moreover, lncRNAs were also considered potential diagnostic and prognostic markers in cancer. The lncRNA small nuclear RNA host gene 16 (SNHG16), found on chromosome 17q25.1, represents a novel tumor-associated lncRNA. SNHG16 was recently found to exhibit dysregulated expression in a variety of malignancies. There are growing evidence of SNHG16’s involvement in characteristics of cancer, including proliferation, apoptosis, together with its involvement in chemoresistance. In addition, SNHG16 has been described as a promising diagnostic and prognostic biomarker in cancer patients. The current review briefly summarizes recently reported findings about SNHG16 and discuss its expression, roles, mechanisms, and diagnostic and prognostic values in human cancers. |
topic |
SNHG16 Long non-coding RNA Human cancer Mechanism Biomarker |
url |
http://link.springer.com/article/10.1186/s40364-020-00221-4 |
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