Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt

Highly pathogenic avian influenza (HPAI) H5N1 and H5N8 have become endemic among domestic poultry in Egypt since 2006 and 2016, respectively. In parallel, the low pathogenic avian influenza H9N2 virus has been endemic since 2010. Despite the continuous circulation of these subtypes for several years...

Full description

Bibliographic Details
Main Authors:	Naglaa M. Hagag, Ahmed M. Erfan, Mohamed El-Husseiny, Azhar G. Shalaby, Mohamed A. Saif, Maram M. Tawakol, Ahmed A. Nour, Abdullah A. Selim, Abdel-Satar Arafa, Mohamed K. Hassan, Wafaa M. M. Hassan, Hanan A. Fahmy, Essam Ibraheem, Mohamed Attia, Ali M. M. Abdelhakim, Momtaz A. Shahein, Mahmoud M. Naguib
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	Viruses
Subjects:	Avian influenza H5N2 H5N8 H9N2 reassortment poultry Egypt
Online Access:	https://www.mdpi.com/1999-4915/11/6/565

id	doaj-75f760235f824f9395decd8d3d262198
record_format	Article
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Naglaa M. Hagag Ahmed M. Erfan Mohamed El-Husseiny Azhar G. Shalaby Mohamed A. Saif Maram M. Tawakol Ahmed A. Nour Abdullah A. Selim Abdel-Satar Arafa Mohamed K. Hassan Wafaa M. M. Hassan Hanan A. Fahmy Essam Ibraheem Mohamed Attia Ali M. M. Abdelhakim Momtaz A. Shahein Mahmoud M. Naguib
spellingShingle	Naglaa M. Hagag Ahmed M. Erfan Mohamed El-Husseiny Azhar G. Shalaby Mohamed A. Saif Maram M. Tawakol Ahmed A. Nour Abdullah A. Selim Abdel-Satar Arafa Mohamed K. Hassan Wafaa M. M. Hassan Hanan A. Fahmy Essam Ibraheem Mohamed Attia Ali M. M. Abdelhakim Momtaz A. Shahein Mahmoud M. Naguib Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt Viruses Avian influenza H5N2 H5N8 H9N2 reassortment poultry Egypt
author_facet	Naglaa M. Hagag Ahmed M. Erfan Mohamed El-Husseiny Azhar G. Shalaby Mohamed A. Saif Maram M. Tawakol Ahmed A. Nour Abdullah A. Selim Abdel-Satar Arafa Mohamed K. Hassan Wafaa M. M. Hassan Hanan A. Fahmy Essam Ibraheem Mohamed Attia Ali M. M. Abdelhakim Momtaz A. Shahein Mahmoud M. Naguib
author_sort	Naglaa M. Hagag
title	Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt
title_short	Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt
title_full	Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt
title_fullStr	Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt
title_full_unstemmed	Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt
title_sort	isolation of a novel reassortant highly pathogenic avian influenza (h5n2) virus in egypt
publisher	MDPI AG
series	Viruses
issn	1999-4915
publishDate	2019-06-01
description	Highly pathogenic avian influenza (HPAI) H5N1 and H5N8 have become endemic among domestic poultry in Egypt since 2006 and 2016, respectively. In parallel, the low pathogenic avian influenza H9N2 virus has been endemic since 2010. Despite the continuous circulation of these subtypes for several years, no natural reassortant has been detected so far among the domestic poultry population in Egypt. In this study, the HPAI (H5N2) virus was isolated from a commercial duck farm, giving evidence of the emergence of the first natural reassortment event in domestic poultry in Egypt. The virus was derived as a result of genetic reassortment between avian influenza viruses of H5N8 and H9N2 subtypes circulating in Egypt. The exchange of the neuraminidase segment and high number of acquired mutations might be associated with an alteration in the biological propensities of this virus.
topic	Avian influenza H5N2 H5N8 H9N2 reassortment poultry Egypt
url	https://www.mdpi.com/1999-4915/11/6/565
work_keys_str_mv	AT naglaamhagag isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT ahmedmerfan isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT mohamedelhusseiny isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT azhargshalaby isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT mohamedasaif isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT marammtawakol isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT ahmedanour isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT abdullahaselim isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT abdelsatararafa isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT mohamedkhassan isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT wafaammhassan isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT hananafahmy isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT essamibraheem isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT mohamedattia isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT alimmabdelhakim isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT momtazashahein isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt AT mahmoudmnaguib isolationofanovelreassortanthighlypathogenicavianinfluenzah5n2virusinegypt
_version_	1724781761651539968
spelling	doaj-75f760235f824f9395decd8d3d2621982020-11-25T02:40:25ZengMDPI AGViruses1999-49152019-06-0111656510.3390/v11060565v11060565Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in EgyptNaglaa M. Hagag0Ahmed M. Erfan1Mohamed El-Husseiny2Azhar G. Shalaby3Mohamed A. Saif4Maram M. Tawakol5Ahmed A. Nour6Abdullah A. Selim7Abdel-Satar Arafa8Mohamed K. Hassan9Wafaa M. M. Hassan10Hanan A. Fahmy11Essam Ibraheem12Mohamed Attia13Ali M. M. Abdelhakim14Momtaz A. Shahein15Mahmoud M. Naguib16National Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptGeneral Organization for Veterinary Services, Nadi El-Said Street P.O. Box, 12619 Dokki, Cairo, Dokki-Giza, EgyptGeneral Organization for Veterinary Services, Nadi El-Said Street P.O. Box, 12619 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptNational Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, 7 Nadi El-Seid Street, 12618 Dokki, Cairo, Dokki-Giza, EgyptHighly pathogenic avian influenza (HPAI) H5N1 and H5N8 have become endemic among domestic poultry in Egypt since 2006 and 2016, respectively. In parallel, the low pathogenic avian influenza H9N2 virus has been endemic since 2010. Despite the continuous circulation of these subtypes for several years, no natural reassortant has been detected so far among the domestic poultry population in Egypt. In this study, the HPAI (H5N2) virus was isolated from a commercial duck farm, giving evidence of the emergence of the first natural reassortment event in domestic poultry in Egypt. The virus was derived as a result of genetic reassortment between avian influenza viruses of H5N8 and H9N2 subtypes circulating in Egypt. The exchange of the neuraminidase segment and high number of acquired mutations might be associated with an alteration in the biological propensities of this virus.https://www.mdpi.com/1999-4915/11/6/565Avian influenzaH5N2H5N8H9N2reassortmentpoultryEgypt

Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt

Similar Items