The Effects of NAD+ on Apoptotic Neuronal Death and Mitochondrial Biogenesis and Function after Glutamate Excitotoxicity

The Effects of NAD+ on Apoptotic Neuronal Death and Mitochondrial Biogenesis and Function after Glutamate Excitotoxicity

NAD+ is an essential co-enzyme for cellular energy metabolism and is also involved as a substrate for many cellular enzymatic reactions. It has been shown that NAD+ has a beneficial effect on neuronal survival and brain injury in in vitro and in vivo ischemic models. However, the effect of NAD+ on m...

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Bibliographic Details
Main Authors: Xiaowan Wang, Hailong Li, Shinghua Ding
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:International Journal of Molecular Sciences
Subjects:
ischemic stroke
glutamate excitotoxicity
apoptosis
AIF
mitochondrial biogenesis
Online Access:http://www.mdpi.com/1422-0067/15/11/20449

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