Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by tran...
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doaj-760a3fce31174cbba43d22b5f90aef292020-11-24T23:47:56ZengHindawi LimitedDisease Markers0278-02401875-86302017-01-01201710.1155/2017/63598716359871Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC DiseaseRayra Pereira Santiago0Camilo Vieira1Corynne Stephanie Ahouefa Adanho2Sanzio Silva Santana3Caroline Conceição Guarda4Camylla Vilas Boas Figueiredo5Luciana Magalhães Fiuza6Thassila Nogueira Pitanga7Junia Raquel Dutra Ferreira8Milena Magalhães Aleluia9Rodrigo Mota Oliveira10Dalila Luciola Zanette11Isa Menezes Lyra12Marilda Souza Goncalves13Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilAmbulatório Pediátrico de Doença Cerebrovascular, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Rua Augusto Viana, s/n, Canela, 40110-060 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilServiço de Pediatria, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Rua Augusto Viana, sn°, Canela, 40110-060 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40.296-710 Salvador, BA, BrazilReference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin. We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration. Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels. Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s. The CAR haplotype was associated with higher TAMMV. In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children. Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx. Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children.http://dx.doi.org/10.1155/2017/6359871 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rayra Pereira Santiago Camilo Vieira Corynne Stephanie Ahouefa Adanho Sanzio Silva Santana Caroline Conceição Guarda Camylla Vilas Boas Figueiredo Luciana Magalhães Fiuza Thassila Nogueira Pitanga Junia Raquel Dutra Ferreira Milena Magalhães Aleluia Rodrigo Mota Oliveira Dalila Luciola Zanette Isa Menezes Lyra Marilda Souza Goncalves |
spellingShingle |
Rayra Pereira Santiago Camilo Vieira Corynne Stephanie Ahouefa Adanho Sanzio Silva Santana Caroline Conceição Guarda Camylla Vilas Boas Figueiredo Luciana Magalhães Fiuza Thassila Nogueira Pitanga Junia Raquel Dutra Ferreira Milena Magalhães Aleluia Rodrigo Mota Oliveira Dalila Luciola Zanette Isa Menezes Lyra Marilda Souza Goncalves Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease Disease Markers |
author_facet |
Rayra Pereira Santiago Camilo Vieira Corynne Stephanie Ahouefa Adanho Sanzio Silva Santana Caroline Conceição Guarda Camylla Vilas Boas Figueiredo Luciana Magalhães Fiuza Thassila Nogueira Pitanga Junia Raquel Dutra Ferreira Milena Magalhães Aleluia Rodrigo Mota Oliveira Dalila Luciola Zanette Isa Menezes Lyra Marilda Souza Goncalves |
author_sort |
Rayra Pereira Santiago |
title |
Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
title_short |
Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
title_full |
Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
title_fullStr |
Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
title_full_unstemmed |
Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
title_sort |
laboratory and genetic biomarkers associated with cerebral blood flow velocity in hemoglobin sc disease |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2017-01-01 |
description |
Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin. We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration. Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels. Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s. The CAR haplotype was associated with higher TAMMV. In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children. Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx. Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children. |
url |
http://dx.doi.org/10.1155/2017/6359871 |
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