Global trends in the incidence and mortality of esophageal cancer from 1990 to 2017
Abstract Background The incidence and mortality of esophageal cancer are high, with 5.90 new cases and 5.48 deaths per 100 000 people worldwide in 2017. The prognosis of esophageal cancer is poor, with an overall 5‐year survival rate of less than 20%. Esophageal cancer in different geographical loca...
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doaj-7612a0a5e54940f29c248d1511a4af8e2020-11-25T02:50:40ZengWileyCancer Medicine2045-76342020-09-019186875688710.1002/cam4.3338Global trends in the incidence and mortality of esophageal cancer from 1990 to 2017Jiahui Fan0Zhenqiu Liu1Xianhua Mao2Xin Tong3Tiejun Zhang4Chen Suo5Xingdong Chen6State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life Sciences Fudan University Shanghai ChinaState Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life Sciences Fudan University Shanghai ChinaState Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life Sciences Fudan University Shanghai ChinaDepartment of Epidemiology & Ministry of Education Key Laboratory of Public Health Safety School of Public Health Fudan University Shanghai ChinaDepartment of Epidemiology & Ministry of Education Key Laboratory of Public Health Safety School of Public Health Fudan University Shanghai ChinaDepartment of Epidemiology & Ministry of Education Key Laboratory of Public Health Safety School of Public Health Fudan University Shanghai ChinaState Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life Sciences Fudan University Shanghai ChinaAbstract Background The incidence and mortality of esophageal cancer are high, with 5.90 new cases and 5.48 deaths per 100 000 people worldwide in 2017. The prognosis of esophageal cancer is poor, with an overall 5‐year survival rate of less than 20%. Esophageal cancer in different geographical locations has different etiologies, and the incidence and mortality of esophageal cancer continue to rise in some regions. Methods We collected incidence and mortality data by age and gender for 195 countries and territories from 1990 to 2017 in the Global Burden of Disease (GBD) database. And we used these data to calculate the estimated annual percentage change (EAPC) to quantify trends in morbidity and mortality. Then we analyzed the gender‐ and age‐specific incidence and mortality in esophageal cancer to targeted high‐risk populations. Finally, we analyzed the correlation between the age‐standardized mortality rate (ASMR) and both the EAPC and social‐demographic index (SDI), and we calculated the Pearson correlation coefficient. Results We found that Malawi, East Asia, and high‐middle SDI regions had the highest age‐standardized incidence rate (ASIR) and ASMR, and the ASIR and ASMR in western Sub‐Saharan Africa showed an upward trend. Our study also showed that the incidence and mortality in esophageal cancer were highest in men and in the 70+ years age group, and they presented a decreasing trend in most regions, but the 15‐49 years age groups in Australasia, Caribbean, and Oceania and the 70+ years age group in High‐Income North America, Oceania and high‐SDI regions presented an increasing trend. There were significant negative associations between ASMR at baseline and EAPC and between ASMR and SDI in 2017. Conclusion By analyzing the global distribution of incidence and mortality in esophageal cancer, trends over time, and gender and age specificity, we can understand the heterogeneity of its global trends. This heterogeneity can help us to identify high‐risk groupsand to provide clues for the exploration of the etiology and early prevention of the disease.https://doi.org/10.1002/cam4.3338age specificitycorrelationesophageal cancergenderspecificitygeographic variationtemporal variation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiahui Fan Zhenqiu Liu Xianhua Mao Xin Tong Tiejun Zhang Chen Suo Xingdong Chen |
spellingShingle |
Jiahui Fan Zhenqiu Liu Xianhua Mao Xin Tong Tiejun Zhang Chen Suo Xingdong Chen Global trends in the incidence and mortality of esophageal cancer from 1990 to 2017 Cancer Medicine age specificity correlation esophageal cancer genderspecificity geographic variation temporal variation |
author_facet |
Jiahui Fan Zhenqiu Liu Xianhua Mao Xin Tong Tiejun Zhang Chen Suo Xingdong Chen |
author_sort |
Jiahui Fan |
title |
Global trends in the incidence and mortality of esophageal cancer from 1990 to 2017 |
title_short |
Global trends in the incidence and mortality of esophageal cancer from 1990 to 2017 |
title_full |
Global trends in the incidence and mortality of esophageal cancer from 1990 to 2017 |
title_fullStr |
Global trends in the incidence and mortality of esophageal cancer from 1990 to 2017 |
title_full_unstemmed |
Global trends in the incidence and mortality of esophageal cancer from 1990 to 2017 |
title_sort |
global trends in the incidence and mortality of esophageal cancer from 1990 to 2017 |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2020-09-01 |
description |
Abstract Background The incidence and mortality of esophageal cancer are high, with 5.90 new cases and 5.48 deaths per 100 000 people worldwide in 2017. The prognosis of esophageal cancer is poor, with an overall 5‐year survival rate of less than 20%. Esophageal cancer in different geographical locations has different etiologies, and the incidence and mortality of esophageal cancer continue to rise in some regions. Methods We collected incidence and mortality data by age and gender for 195 countries and territories from 1990 to 2017 in the Global Burden of Disease (GBD) database. And we used these data to calculate the estimated annual percentage change (EAPC) to quantify trends in morbidity and mortality. Then we analyzed the gender‐ and age‐specific incidence and mortality in esophageal cancer to targeted high‐risk populations. Finally, we analyzed the correlation between the age‐standardized mortality rate (ASMR) and both the EAPC and social‐demographic index (SDI), and we calculated the Pearson correlation coefficient. Results We found that Malawi, East Asia, and high‐middle SDI regions had the highest age‐standardized incidence rate (ASIR) and ASMR, and the ASIR and ASMR in western Sub‐Saharan Africa showed an upward trend. Our study also showed that the incidence and mortality in esophageal cancer were highest in men and in the 70+ years age group, and they presented a decreasing trend in most regions, but the 15‐49 years age groups in Australasia, Caribbean, and Oceania and the 70+ years age group in High‐Income North America, Oceania and high‐SDI regions presented an increasing trend. There were significant negative associations between ASMR at baseline and EAPC and between ASMR and SDI in 2017. Conclusion By analyzing the global distribution of incidence and mortality in esophageal cancer, trends over time, and gender and age specificity, we can understand the heterogeneity of its global trends. This heterogeneity can help us to identify high‐risk groupsand to provide clues for the exploration of the etiology and early prevention of the disease. |
topic |
age specificity correlation esophageal cancer genderspecificity geographic variation temporal variation |
url |
https://doi.org/10.1002/cam4.3338 |
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