CDK1 dependent phosphorylation of hTERT contributes to cancer progression

Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for reverse transcriptase and terminal transferase acti...

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Main Authors:	Mami Yasukawa, Yoshinari Ando, Taro Yamashita, Yoko Matsuda, Shisako Shoji, Masaki Suimye Morioka, Hideya Kawaji, Kumiko Shiozawa, Mitsuhiro Machitani, Takaya Abe, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, Yasuhide Furuta, Tadashi Kondo, Mikako Shirouzu, Yoshihide Hayashizaki, Shuichi Kaneko, Kenkichi Masutomi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15289-7

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spelling	doaj-761b43ac125a4eb99158e2f0b22fb7cd2021-05-11T08:40:14ZengNature Publishing GroupNature Communications2041-17232020-03-0111111810.1038/s41467-020-15289-7CDK1 dependent phosphorylation of hTERT contributes to cancer progressionMami Yasukawa0Yoshinari Ando1Taro Yamashita2Yoko Matsuda3Shisako Shoji4Masaki Suimye Morioka5Hideya Kawaji6Kumiko Shiozawa7Mitsuhiro Machitani8Takaya Abe9Shinji Yamada10Mika K. Kaneko11Yukinari Kato12Yasuhide Furuta13Tadashi Kondo14Mikako Shirouzu15Yoshihide Hayashizaki16Shuichi Kaneko17Kenkichi Masutomi18Division of Cancer Stem Cell, National Cancer Center Research InstituteDivision of Cancer Stem Cell, National Cancer Center Research InstituteDepartment of Gastroenterology, Kanazawa University Graduate School of Medical ScienceDepartment of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of GerontologyLaboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics ResearchPreventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical SciencesPreventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical SciencesDivision of Rare Cancer Research, National Cancer Center Research InstituteDivision of Cancer Stem Cell, National Cancer Center Research InstituteAnimal Resource Development Unit, RIKEN Center for Life Science TechnologiesDepartment of Antibody Drug Development, Tohoku University Graduate School of MedicineDepartment of Antibody Drug Development, Tohoku University Graduate School of MedicineDepartment of Antibody Drug Development, Tohoku University Graduate School of MedicineAnimal Resource Development Unit, RIKEN Center for Life Science TechnologiesDivision of Rare Cancer Research, National Cancer Center Research InstituteLaboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics ResearchRIKEN Preventive Medicine and Diagnosis Innovation ProgramDepartment of Gastroenterology, Kanazawa University Graduate School of Medical ScienceDivision of Cancer Stem Cell, National Cancer Center Research InstituteRegulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for reverse transcriptase and terminal transferase activities.https://doi.org/10.1038/s41467-020-15289-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mami Yasukawa Yoshinari Ando Taro Yamashita Yoko Matsuda Shisako Shoji Masaki Suimye Morioka Hideya Kawaji Kumiko Shiozawa Mitsuhiro Machitani Takaya Abe Shinji Yamada Mika K. Kaneko Yukinari Kato Yasuhide Furuta Tadashi Kondo Mikako Shirouzu Yoshihide Hayashizaki Shuichi Kaneko Kenkichi Masutomi
spellingShingle	Mami Yasukawa Yoshinari Ando Taro Yamashita Yoko Matsuda Shisako Shoji Masaki Suimye Morioka Hideya Kawaji Kumiko Shiozawa Mitsuhiro Machitani Takaya Abe Shinji Yamada Mika K. Kaneko Yukinari Kato Yasuhide Furuta Tadashi Kondo Mikako Shirouzu Yoshihide Hayashizaki Shuichi Kaneko Kenkichi Masutomi CDK1 dependent phosphorylation of hTERT contributes to cancer progression Nature Communications
author_facet	Mami Yasukawa Yoshinari Ando Taro Yamashita Yoko Matsuda Shisako Shoji Masaki Suimye Morioka Hideya Kawaji Kumiko Shiozawa Mitsuhiro Machitani Takaya Abe Shinji Yamada Mika K. Kaneko Yukinari Kato Yasuhide Furuta Tadashi Kondo Mikako Shirouzu Yoshihide Hayashizaki Shuichi Kaneko Kenkichi Masutomi
author_sort	Mami Yasukawa
title	CDK1 dependent phosphorylation of hTERT contributes to cancer progression
title_short	CDK1 dependent phosphorylation of hTERT contributes to cancer progression
title_full	CDK1 dependent phosphorylation of hTERT contributes to cancer progression
title_fullStr	CDK1 dependent phosphorylation of hTERT contributes to cancer progression
title_full_unstemmed	CDK1 dependent phosphorylation of hTERT contributes to cancer progression
title_sort	cdk1 dependent phosphorylation of htert contributes to cancer progression
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-03-01
description	Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for reverse transcriptase and terminal transferase activities.
url	https://doi.org/10.1038/s41467-020-15289-7
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CDK1 dependent phosphorylation of hTERT contributes to cancer progression

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