Local delivery of chemotherapeutic agent in tissue engineering based on gelatin/graphene hydrogel
Repairing and replacing of tumor tissues have been grown due to the genetic changes and environmental factors. Conventional cancer therapies apply the systemic approaches for delivery of anticancer agents in which normal and cancer cells are not discriminated. Therefore, the risk of cancer recurrenc...
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doaj-762053ccb9204820948fdc101a3c84ae2021-05-24T04:30:26ZengElsevierJournal of Materials Research and Technology2238-78542021-05-0112412422Local delivery of chemotherapeutic agent in tissue engineering based on gelatin/graphene hydrogelEsfandyar Askari0Seyed Morteza Naghib1Alireza Zahedi2Amir Seyfoori3Yasser Zare4Kyong Yop Rhee5Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran, Iran; Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, IranNanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran, Iran; Corresponding author.Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran, IranBiomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, IranBiomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, IranDepartment of Mechanical Engineering (BK21 Four), College of Engineering, Kyung Hee University, Yongin, Republic of Korea; Corresponding author.Repairing and replacing of tumor tissues have been grown due to the genetic changes and environmental factors. Conventional cancer therapies apply the systemic approaches for delivery of anticancer agents in which normal and cancer cells are not discriminated. Therefore, the risk of cancer recurrence in the resection site increases. In this paper, we studied a graphene reinforced gelatin hydrogel for tissue engineering and local controlled release of chemotherapeutic agents. Protein-integrated graphene (PIG) synthesized by ultrasonic-supported technique was incorporated into gelatin matrix, where the swelling ratio of hydrogels decreased with increasing the PIG concentration. In hydrogels, doxorubicin (DOX) was released in a controlled and pH-sensitive manner and the release rate was controlled by PIG concentration. The effect of PIG on the controlled release system was detected in MCF-7 cell viability. Moreover, 3D tumor spheroid test studied the extracellular matrix (ECM) and cell aggregation as an in vivo model. Generally, we introduced a novel hydrogel nanocomposite, which is a suitable candidate for post-surgery treatment and localized therapy.http://www.sciencedirect.com/science/article/pii/S2238785421002106GrapheneGelatinLocal deliveryMechanical properties3D in vitro tumor models |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Esfandyar Askari Seyed Morteza Naghib Alireza Zahedi Amir Seyfoori Yasser Zare Kyong Yop Rhee |
spellingShingle |
Esfandyar Askari Seyed Morteza Naghib Alireza Zahedi Amir Seyfoori Yasser Zare Kyong Yop Rhee Local delivery of chemotherapeutic agent in tissue engineering based on gelatin/graphene hydrogel Journal of Materials Research and Technology Graphene Gelatin Local delivery Mechanical properties 3D in vitro tumor models |
author_facet |
Esfandyar Askari Seyed Morteza Naghib Alireza Zahedi Amir Seyfoori Yasser Zare Kyong Yop Rhee |
author_sort |
Esfandyar Askari |
title |
Local delivery of chemotherapeutic agent in tissue engineering based on gelatin/graphene hydrogel |
title_short |
Local delivery of chemotherapeutic agent in tissue engineering based on gelatin/graphene hydrogel |
title_full |
Local delivery of chemotherapeutic agent in tissue engineering based on gelatin/graphene hydrogel |
title_fullStr |
Local delivery of chemotherapeutic agent in tissue engineering based on gelatin/graphene hydrogel |
title_full_unstemmed |
Local delivery of chemotherapeutic agent in tissue engineering based on gelatin/graphene hydrogel |
title_sort |
local delivery of chemotherapeutic agent in tissue engineering based on gelatin/graphene hydrogel |
publisher |
Elsevier |
series |
Journal of Materials Research and Technology |
issn |
2238-7854 |
publishDate |
2021-05-01 |
description |
Repairing and replacing of tumor tissues have been grown due to the genetic changes and environmental factors. Conventional cancer therapies apply the systemic approaches for delivery of anticancer agents in which normal and cancer cells are not discriminated. Therefore, the risk of cancer recurrence in the resection site increases. In this paper, we studied a graphene reinforced gelatin hydrogel for tissue engineering and local controlled release of chemotherapeutic agents. Protein-integrated graphene (PIG) synthesized by ultrasonic-supported technique was incorporated into gelatin matrix, where the swelling ratio of hydrogels decreased with increasing the PIG concentration. In hydrogels, doxorubicin (DOX) was released in a controlled and pH-sensitive manner and the release rate was controlled by PIG concentration. The effect of PIG on the controlled release system was detected in MCF-7 cell viability. Moreover, 3D tumor spheroid test studied the extracellular matrix (ECM) and cell aggregation as an in vivo model. Generally, we introduced a novel hydrogel nanocomposite, which is a suitable candidate for post-surgery treatment and localized therapy. |
topic |
Graphene Gelatin Local delivery Mechanical properties 3D in vitro tumor models |
url |
http://www.sciencedirect.com/science/article/pii/S2238785421002106 |
work_keys_str_mv |
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1721429002697048064 |