Targeting Mitochondrial Oncometabolites: A New Approach to Overcome Drug Resistance in Cancer

Targeting Mitochondrial Oncometabolites: A New Approach to Overcome Drug Resistance in Cancer

Drug resistance is the main obstacle for a successful cancer therapy. There are many mechanisms by which cancers avoid drug-mediated death, including alterations in cellular metabolism and apoptotic programs. Mitochondria represent the cell’s powerhouse and the connection between carbohydrate, lipid...

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Bibliographic Details
Main Authors: Martina Godel, Giacomo Ortone, Dario Pasquale Anobile, Martina Pasino, Giulio Randazzo, Chiara Riganti, Joanna Kopecka
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
mitochondrial oncometabolites
cancer drug resistance
cancer metabolism
Online Access:https://www.mdpi.com/1999-4923/13/5/762

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