Total antioxidant and oxidant status in obese children without insulin resistance
Objective: Oxidative stress in obese children may lead in adulthood serious conditions such as coronary heart diseases or type 2 diabetes mellitus. In childhood oxidative stress is associated with insulin resistance or extreme obesity. In this study, we aimed to evaluate oxidative stress status in...
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doaj-7620f70c7be24a4e938ab2bb92a141d92020-11-24T21:16:49ZengDicle University Medical SchoolDicle Medical Journal 1300-29451308-98892014-06-0141225726110.5798/diclemedj.0921.2014.02.0412Total antioxidant and oxidant status in obese children without insulin resistanceAyşegül Doğan Demir0Ufuk Erenberk1İlker Tolga Özgen2Emin Özkaya 3Aysel Vahapoğlu Türkmen4M. Ruşen Dündaröz5Özcan Erel6Bezmi Alem Vakif University Faculty of Medicine, Department of Pediatrics, İstanbulBezmi Alem Vakif University Faculty of Medicine, Department of Pediatrics, İstanbulBezmi Alem Vakif University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, İstanbulBezmi Alem Vakif University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Allergy, İstanbulBezmi Alem Vakif University Faculty of Medicine, Department of Pediatrics, İstanbulBezmi Alem Vakif University Faculty of Medicine, Department of Pediatrics, İstanbul Yıldırım Beyazıt University Faculty of Medicine, Department of Medical Biochemistry , İstanbul Objective: Oxidative stress in obese children may lead in adulthood serious conditions such as coronary heart diseases or type 2 diabetes mellitus. In childhood oxidative stress is associated with insulin resistance or extreme obesity. In this study, we aimed to evaluate oxidative stress status in moderately obese children without insulin resistance. Methods: A total of 38 obese children (21 male, 17 female) without insulin resistance, mean aged 9.4±3.8 years) and 51 normal weight children (25 male, 26 female) as the control group, mean aged 9.3±3.9 years) were enrolled to the study. Total oxidative status (TOS), total antioxidant capacity (TAC) were measured and oxidative stress index (OSI) was calculated. Results: The results reveal that obese children had lower TAC than normal weight children (2,27±0,28 vs. 2.76±0.35 mmol Trolox Eq./L; p<0,001). There was no statistical difference between obese and control groups regarding TOS (6,08±3,63 vs 5.25±4.16 μmol H2O2 Eq./L; p=0.333). OSI was higher in obese group (2.65±1.52 vs 1.92±1.56; p=0.029) Conclusion: Balance between oxidant and antioxidant system is disrupted due to the reduced TAC even in moderately obese children without insulin resistance. Further studies should also be performed to evaluate the beneficial effects of dietary intake of antioxidants in these children.http://www.diclemedj.org/upload/sayi/32/Dicle%20Med%20J-01985.pdfchildrenobesity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ayşegül Doğan Demir Ufuk Erenberk İlker Tolga Özgen Emin Özkaya Aysel Vahapoğlu Türkmen M. Ruşen Dündaröz Özcan Erel |
spellingShingle |
Ayşegül Doğan Demir Ufuk Erenberk İlker Tolga Özgen Emin Özkaya Aysel Vahapoğlu Türkmen M. Ruşen Dündaröz Özcan Erel Total antioxidant and oxidant status in obese children without insulin resistance Dicle Medical Journal children obesity |
author_facet |
Ayşegül Doğan Demir Ufuk Erenberk İlker Tolga Özgen Emin Özkaya Aysel Vahapoğlu Türkmen M. Ruşen Dündaröz Özcan Erel |
author_sort |
Ayşegül Doğan Demir |
title |
Total antioxidant and oxidant status in obese children without insulin resistance |
title_short |
Total antioxidant and oxidant status in obese children without insulin resistance |
title_full |
Total antioxidant and oxidant status in obese children without insulin resistance |
title_fullStr |
Total antioxidant and oxidant status in obese children without insulin resistance |
title_full_unstemmed |
Total antioxidant and oxidant status in obese children without insulin resistance |
title_sort |
total antioxidant and oxidant status in obese children without insulin resistance |
publisher |
Dicle University Medical School |
series |
Dicle Medical Journal |
issn |
1300-2945 1308-9889 |
publishDate |
2014-06-01 |
description |
Objective: Oxidative stress in obese children may lead in adulthood serious conditions such as coronary heart diseases or type 2 diabetes mellitus. In childhood oxidative stress is associated with insulin resistance or extreme obesity. In this study, we aimed to evaluate oxidative stress status in moderately obese children without insulin resistance.
Methods: A total of 38 obese children (21 male, 17 female) without insulin resistance, mean aged 9.4±3.8 years) and 51 normal weight children (25 male, 26 female) as the control group, mean aged 9.3±3.9 years) were enrolled to the study. Total oxidative status (TOS), total antioxidant capacity (TAC) were measured and oxidative stress index (OSI) was calculated.
Results: The results reveal that obese children had lower TAC than normal weight children (2,27±0,28 vs. 2.76±0.35 mmol Trolox Eq./L; p<0,001). There was no statistical difference between obese and control groups regarding TOS (6,08±3,63 vs 5.25±4.16 μmol H2O2 Eq./L; p=0.333). OSI was higher in obese group (2.65±1.52 vs 1.92±1.56; p=0.029)
Conclusion: Balance between oxidant and antioxidant system is disrupted due to the reduced TAC even in moderately obese children without insulin resistance. Further studies should also be performed to evaluate the beneficial effects of dietary intake of antioxidants in these children. |
topic |
children obesity |
url |
http://www.diclemedj.org/upload/sayi/32/Dicle%20Med%20J-01985.pdf |
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