Total antioxidant and oxidant status in obese children without insulin resistance

• Main Authors: Ayşegül Doğan Demir, Ufuk Erenberk, İlker Tolga Özgen, Emin Özkaya, Aysel Vahapoğlu Türkmen, M. Ruşen Dündaröz, Özcan Erel
• Format: Article
• Language: English
• Published: Dicle University Medical School 2014-06-01
• Series: Dicle Medical Journal
• Subjects: children; obesity
• Online Access: http://www.diclemedj.org/upload/sayi/32/Dicle%20Med%20J-01985.pdf

Objective: Oxidative stress in obese children may lead in adulthood serious conditions such as coronary heart diseases or type 2 diabetes mellitus. In childhood oxidative stress is associated with insulin resistance or extreme obesity. In this study, we aimed to evaluate oxidative stress status in moderately obese children without insulin resistance. Methods: A total of 38 obese children (21 male, 17 female) without insulin resistance, mean aged 9.4±3.8 years) and 51 normal weight children (25 male, 26 female) as the control group, mean aged 9.3±3.9 years) were enrolled to the study. Total oxidative status (TOS), total antioxidant capacity (TAC) were measured and oxidative stress index (OSI) was calculated. Results: The results reveal that obese children had lower TAC than normal weight children (2,27±0,28 vs. 2.76±0.35 mmol Trolox Eq./L; p<0,001). There was no statistical difference between obese and control groups regarding TOS (6,08±3,63 vs 5.25±4.16 μmol H2O2 Eq./L; p=0.333). OSI was higher in obese group (2.65±1.52 vs 1.92±1.56; p=0.029) Conclusion: Balance between oxidant and antioxidant system is disrupted due to the reduced TAC even in moderately obese children without insulin resistance. Further studies should also be performed to evaluate the beneficial effects of dietary intake of antioxidants in these children.