Factors That Affect the False-Negative Outcomes of Fine-Needle Aspiration Biopsy in Thyroid Nodules
Background. The purpose of this study was to assess the factors that affect the false-negative outcomes of fine-needle aspiration biopsies (FNABs) in thyroid nodules. Methods. Thyroid nodules that underwent FNAB and surgery between August 2005 and January 2012 were analyzed. FNABs were taken from th...
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doaj-7621836dd3ce4667b9a7c680bd3bab832020-11-25T00:04:40ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/126084126084Factors That Affect the False-Negative Outcomes of Fine-Needle Aspiration Biopsy in Thyroid NodulesOrhan Agcaoglu0Nihat Aksakal1Beyza Ozcinar2Inanc S. Sarici3Gulcin Ercan4Meltem Kucukyilmaz5Fatih Yanar6Ibrahim A. Ozemir7Berkay Kilic8Kasim Caglayan9Dilek Yilmazbayhan10Artur Salmaslioglu11Halim Issever12Selcuk Ozarmagan13Yesim Erbil14Department of General Surgery, Istanbul Medical School, Istanbul University, 34493 Capa, Istanbul, TurkeyDepartment of General Surgery, Istanbul Medical School, Istanbul University, 34493 Capa, Istanbul, TurkeyDepartment of General Surgery, Istanbul Medical School, Istanbul University, 34493 Capa, Istanbul, TurkeyDepartment of General Surgery, Istanbul Medical School, Istanbul University, 34493 Capa, Istanbul, TurkeyGeneral Surgery Clinic, Bagcilar Research and Training Hospital, Istanbul, TurkeyGeneral Surgery Clinic, Bagcilar Research and Training Hospital, Istanbul, TurkeyDepartment of General Surgery, Istanbul Medical School, Istanbul University, 34493 Capa, Istanbul, TurkeyDepartment of General Surgery, Istanbul Medical School, Istanbul University, 34493 Capa, Istanbul, TurkeyDepartment of General Surgery, Istanbul Medical School, Istanbul University, 34493 Capa, Istanbul, TurkeyDepartment of General Surgery, Istanbul Medical School, Istanbul University, 34493 Capa, Istanbul, TurkeyDepartment of Pathology, Istanbul Medical School, Istanbul University, Istanbul, TurkeyDepartment of Radiology, Istanbul Medical School, Istanbul University, Istanbul, TurkeyDepartment of Public Health, Istanbul Medical School, Istanbul University, Istanbul, TurkeyDepartment of General Surgery, Istanbul Medical School, Istanbul University, 34493 Capa, Istanbul, TurkeyDepartment of General Surgery, Istanbul Medical School, Istanbul University, 34493 Capa, Istanbul, TurkeyBackground. The purpose of this study was to assess the factors that affect the false-negative outcomes of fine-needle aspiration biopsies (FNABs) in thyroid nodules. Methods. Thyroid nodules that underwent FNAB and surgery between August 2005 and January 2012 were analyzed. FNABs were taken from the suspicious nodules regardless of nodule size. Results. Nodules were analyzed in 2 different groups: Group 1 was the false-negatives (n=81) and Group 2 was the remaining true-positives, true-negatives, and false-positives (n=649). A cytopathologist attended in 559 (77%) of FNAB procedures. There was a positive correlation between the nodule size and false-negative rates, and the absence of an interpreting cytopathologist for the examination of the FNAB procedure was the most significant parameter with a 76-fold increased risk of false-negative results. Conclusion. The contribution of cytopathologists extends the time of the procedure, and this could be a difficult practice in centres with high patient turnovers. We currently request the contribution of a cytopathologist for selected patients whom should be followed up without surgery.http://dx.doi.org/10.1155/2013/126084 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Orhan Agcaoglu Nihat Aksakal Beyza Ozcinar Inanc S. Sarici Gulcin Ercan Meltem Kucukyilmaz Fatih Yanar Ibrahim A. Ozemir Berkay Kilic Kasim Caglayan Dilek Yilmazbayhan Artur Salmaslioglu Halim Issever Selcuk Ozarmagan Yesim Erbil |
spellingShingle |
Orhan Agcaoglu Nihat Aksakal Beyza Ozcinar Inanc S. Sarici Gulcin Ercan Meltem Kucukyilmaz Fatih Yanar Ibrahim A. Ozemir Berkay Kilic Kasim Caglayan Dilek Yilmazbayhan Artur Salmaslioglu Halim Issever Selcuk Ozarmagan Yesim Erbil Factors That Affect the False-Negative Outcomes of Fine-Needle Aspiration Biopsy in Thyroid Nodules International Journal of Endocrinology |
author_facet |
Orhan Agcaoglu Nihat Aksakal Beyza Ozcinar Inanc S. Sarici Gulcin Ercan Meltem Kucukyilmaz Fatih Yanar Ibrahim A. Ozemir Berkay Kilic Kasim Caglayan Dilek Yilmazbayhan Artur Salmaslioglu Halim Issever Selcuk Ozarmagan Yesim Erbil |
author_sort |
Orhan Agcaoglu |
title |
Factors That Affect the False-Negative Outcomes of Fine-Needle Aspiration Biopsy in Thyroid Nodules |
title_short |
Factors That Affect the False-Negative Outcomes of Fine-Needle Aspiration Biopsy in Thyroid Nodules |
title_full |
Factors That Affect the False-Negative Outcomes of Fine-Needle Aspiration Biopsy in Thyroid Nodules |
title_fullStr |
Factors That Affect the False-Negative Outcomes of Fine-Needle Aspiration Biopsy in Thyroid Nodules |
title_full_unstemmed |
Factors That Affect the False-Negative Outcomes of Fine-Needle Aspiration Biopsy in Thyroid Nodules |
title_sort |
factors that affect the false-negative outcomes of fine-needle aspiration biopsy in thyroid nodules |
publisher |
Hindawi Limited |
series |
International Journal of Endocrinology |
issn |
1687-8337 1687-8345 |
publishDate |
2013-01-01 |
description |
Background. The purpose of this study was to assess the factors that affect the false-negative outcomes of fine-needle aspiration biopsies (FNABs) in thyroid nodules. Methods. Thyroid nodules that underwent FNAB and surgery between August 2005 and January 2012 were analyzed. FNABs were taken from the suspicious nodules regardless of nodule size. Results. Nodules were analyzed in 2 different groups: Group 1 was the false-negatives (n=81) and Group 2 was the remaining true-positives, true-negatives, and false-positives (n=649). A cytopathologist attended in 559 (77%) of FNAB procedures. There was a positive correlation between the nodule size and false-negative rates, and the absence of an interpreting cytopathologist for the examination of the FNAB procedure was the most significant parameter with a 76-fold increased risk of false-negative results. Conclusion. The contribution of cytopathologists extends the time of the procedure, and this could be a difficult practice in centres with high patient turnovers. We currently request the contribution of a cytopathologist for selected patients whom should be followed up without surgery. |
url |
http://dx.doi.org/10.1155/2013/126084 |
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