Chemerin level in a sample of Egyptian females with PCOS and its relation to insulin resistance
Abstract Background Chemerin a novel adipokine is linked to insulin resistance and adiposity which are major characteristics of polycystic ovary syndrome (PCOS). Results Chemerin level was found to be significantly higher in PCOS group than in control group (94.99 ± 12.52 ng/dl vs 73.41 ± 6.95 ng/dl...
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2020-11-01
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Online Access: | http://link.springer.com/article/10.1186/s43162-020-00019-8 |
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doaj-7624440d8fe74b99a716f92efc29798e2020-11-25T04:07:18ZengSpringerOpenThe Egyptian Journal of Internal Medicine1110-77822090-90982020-11-013211510.1186/s43162-020-00019-8Chemerin level in a sample of Egyptian females with PCOS and its relation to insulin resistanceMohamed Reda Halawa0Rania Said Abd El Baky1Yara Mohamed Eid2Merhan Samy Nasr3Bahaa Mahmoud Taha4Laila Mahmoud Ali Hendawy5Ain Shams University HospitalAin Shams University HospitalAin Shams University HospitalAin Shams University HospitalAin Shams University HospitalAin Shams University HospitalAbstract Background Chemerin a novel adipokine is linked to insulin resistance and adiposity which are major characteristics of polycystic ovary syndrome (PCOS). Results Chemerin level was found to be significantly higher in PCOS group than in control group (94.99 ± 12.52 ng/dl vs 73.41 ± 6.95 ng/dl) (P < 0.001) being the highest in obese PCO group, also chemerin positively correlated with BMI, fasting insulin, and HOMA-IR (P < 0.001), Multivariate linear regression analysis for factors affecting chemerin level in both PCO groups showed that the most important factor was fasting insulin (P = 0.042). Conclusion Chemerin correlates with insulin resistance and may be involved in the pathogenesis of insulin resistance in PCOS patients.http://link.springer.com/article/10.1186/s43162-020-00019-8Insulin resistanceChemerinPCOS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohamed Reda Halawa Rania Said Abd El Baky Yara Mohamed Eid Merhan Samy Nasr Bahaa Mahmoud Taha Laila Mahmoud Ali Hendawy |
spellingShingle |
Mohamed Reda Halawa Rania Said Abd El Baky Yara Mohamed Eid Merhan Samy Nasr Bahaa Mahmoud Taha Laila Mahmoud Ali Hendawy Chemerin level in a sample of Egyptian females with PCOS and its relation to insulin resistance The Egyptian Journal of Internal Medicine Insulin resistance Chemerin PCOS |
author_facet |
Mohamed Reda Halawa Rania Said Abd El Baky Yara Mohamed Eid Merhan Samy Nasr Bahaa Mahmoud Taha Laila Mahmoud Ali Hendawy |
author_sort |
Mohamed Reda Halawa |
title |
Chemerin level in a sample of Egyptian females with PCOS and its relation to insulin resistance |
title_short |
Chemerin level in a sample of Egyptian females with PCOS and its relation to insulin resistance |
title_full |
Chemerin level in a sample of Egyptian females with PCOS and its relation to insulin resistance |
title_fullStr |
Chemerin level in a sample of Egyptian females with PCOS and its relation to insulin resistance |
title_full_unstemmed |
Chemerin level in a sample of Egyptian females with PCOS and its relation to insulin resistance |
title_sort |
chemerin level in a sample of egyptian females with pcos and its relation to insulin resistance |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Internal Medicine |
issn |
1110-7782 2090-9098 |
publishDate |
2020-11-01 |
description |
Abstract Background Chemerin a novel adipokine is linked to insulin resistance and adiposity which are major characteristics of polycystic ovary syndrome (PCOS). Results Chemerin level was found to be significantly higher in PCOS group than in control group (94.99 ± 12.52 ng/dl vs 73.41 ± 6.95 ng/dl) (P < 0.001) being the highest in obese PCO group, also chemerin positively correlated with BMI, fasting insulin, and HOMA-IR (P < 0.001), Multivariate linear regression analysis for factors affecting chemerin level in both PCO groups showed that the most important factor was fasting insulin (P = 0.042). Conclusion Chemerin correlates with insulin resistance and may be involved in the pathogenesis of insulin resistance in PCOS patients. |
topic |
Insulin resistance Chemerin PCOS |
url |
http://link.springer.com/article/10.1186/s43162-020-00019-8 |
work_keys_str_mv |
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