Deciphering the effect of reproductive tract microbiota on human reproduction
Abstract Background The female reproductive tract contains an active microbiome comprising mainly bacteria from the Lactobacillus genus, which is associated with a healthy microbiome state. However, spatio‐temporal fluctuations of this microbiome that occur in response to internal and external facto...
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Online Access: | https://doi.org/10.1002/rmb2.12249 |
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doaj-7635fc20e7e74405a51adb8dabb1c1162020-11-25T00:06:36ZengWileyReproductive Medicine and Biology1445-57811447-05782019-01-01181405010.1002/rmb2.12249Deciphering the effect of reproductive tract microbiota on human reproductionInmaculada Moreno0Carlos Simon1Igenomix Foundation Parque Tecnologico de Paterna Valencia SpainIgenomix Foundation Parque Tecnologico de Paterna Valencia SpainAbstract Background The female reproductive tract contains an active microbiome comprising mainly bacteria from the Lactobacillus genus, which is associated with a healthy microbiome state. However, spatio‐temporal fluctuations of this microbiome that occur in response to internal and external factors may impact the physiology of the reproductive tract organs and even lead to pathological states. Methods Current literature covering the reproductive tract microbiome is summarized and contextualized in this review. Main findings This review presents the current knowledge about the bacterial composition of the lower and upper reproductive tract as well as the impact of the microbiota on women's health and reproduction. We place special focus on the impact of the endometrial microbiome in infertility and assisted reproductive technologies. Conclusion The assessment of the reproductive tract microbiome adds a new microbiological perspective to human reproduction, pregnancy, and onset of new life, highlighting the importance of considering the evaluation of microbial communities to improve personalized care in reproductive medicine and women's health.https://doi.org/10.1002/rmb2.12249dysbiosisendometrial healthhuman reproductionmicrobiomereproductive tract bacteria |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Inmaculada Moreno Carlos Simon |
spellingShingle |
Inmaculada Moreno Carlos Simon Deciphering the effect of reproductive tract microbiota on human reproduction Reproductive Medicine and Biology dysbiosis endometrial health human reproduction microbiome reproductive tract bacteria |
author_facet |
Inmaculada Moreno Carlos Simon |
author_sort |
Inmaculada Moreno |
title |
Deciphering the effect of reproductive tract microbiota on human reproduction |
title_short |
Deciphering the effect of reproductive tract microbiota on human reproduction |
title_full |
Deciphering the effect of reproductive tract microbiota on human reproduction |
title_fullStr |
Deciphering the effect of reproductive tract microbiota on human reproduction |
title_full_unstemmed |
Deciphering the effect of reproductive tract microbiota on human reproduction |
title_sort |
deciphering the effect of reproductive tract microbiota on human reproduction |
publisher |
Wiley |
series |
Reproductive Medicine and Biology |
issn |
1445-5781 1447-0578 |
publishDate |
2019-01-01 |
description |
Abstract Background The female reproductive tract contains an active microbiome comprising mainly bacteria from the Lactobacillus genus, which is associated with a healthy microbiome state. However, spatio‐temporal fluctuations of this microbiome that occur in response to internal and external factors may impact the physiology of the reproductive tract organs and even lead to pathological states. Methods Current literature covering the reproductive tract microbiome is summarized and contextualized in this review. Main findings This review presents the current knowledge about the bacterial composition of the lower and upper reproductive tract as well as the impact of the microbiota on women's health and reproduction. We place special focus on the impact of the endometrial microbiome in infertility and assisted reproductive technologies. Conclusion The assessment of the reproductive tract microbiome adds a new microbiological perspective to human reproduction, pregnancy, and onset of new life, highlighting the importance of considering the evaluation of microbial communities to improve personalized care in reproductive medicine and women's health. |
topic |
dysbiosis endometrial health human reproduction microbiome reproductive tract bacteria |
url |
https://doi.org/10.1002/rmb2.12249 |
work_keys_str_mv |
AT inmaculadamoreno decipheringtheeffectofreproductivetractmicrobiotaonhumanreproduction AT carlossimon decipheringtheeffectofreproductivetractmicrobiotaonhumanreproduction |
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