Autologous platelet-rich plasma eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects
Purpose: To investigate whether autologous platelet-rich plasma (PRP) eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects (PEDs). Methods: A total of 34 eyes with PEDs after keratoplasty (24 penetrating keratoplasty and 10 deep anterior lamellar kerat...
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doaj-7636431a0f7549e98f44f3ecd639edcb2020-11-25T02:00:24ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2019-01-0114213113510.4103/jovr.jovr_279_17Autologous platelet-rich plasma eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defectsShaban AlizadehSahar BalagholiAlireza Baradaran-RafiiSiamak Delfaza-BaherSare SafiHamid SafiRasul DabbaghiMozhgan Rezaei KanaviPurpose: To investigate whether autologous platelet-rich plasma (PRP) eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects (PEDs). Methods: A total of 34 eyes with PEDs after keratoplasty (24 penetrating keratoplasty and 10 deep anterior lamellar keratoplasty) that were refractory to conventional medical treatments were treated with PRP eye drops every 3 hours. PRP eye drops were prepared with a low- and high-speed centrifugation method and final platelet counts were 700,000-800,000 plt/μl. The mean treatment duration for complete re-epithelialization was compared with the mean treatment duration of conventionally treated corneal defects before the PRP treatment by paired t-test. The mean treatment duration was also statistically analyzed between age groups, gender, indications for keratoplasty, and types of keratoplasty using analysis of variance (ANOVA). Results: Treatment with autologous PRP eye drops led to rapid re-epithelialization in all eyes. The mean treatment duration for complete re-epithelialization was 2.47 ± 1.21 weeks, which was significantly shorter than the mean treatment duration of conventionally treated corneal defects before PRP treatment (6.82 ± 1.24 weeks) (P = 0.0001). There was no significant correlation between re-epithelialization time and patients' age, sex, indications for keratoplasty, and techniques of corneal transplantation. Conclusion: Treatment with autologous PRP eye drops is an effective and reliable approach that accelerates re-epithelialization of post-transplantation PEDs.http://www.jovr.org/article.asp?issn=2008-322X;year=2019;volume=14;issue=2;spage=131;epage=135;aulast=AlizadehCorneal Epithelial Defects; Eye Drop; Healing; Keratoplasty; PED; Platelet |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shaban Alizadeh Sahar Balagholi Alireza Baradaran-Rafii Siamak Delfaza-Baher Sare Safi Hamid Safi Rasul Dabbaghi Mozhgan Rezaei Kanavi |
spellingShingle |
Shaban Alizadeh Sahar Balagholi Alireza Baradaran-Rafii Siamak Delfaza-Baher Sare Safi Hamid Safi Rasul Dabbaghi Mozhgan Rezaei Kanavi Autologous platelet-rich plasma eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects Journal of Ophthalmic & Vision Research Corneal Epithelial Defects; Eye Drop; Healing; Keratoplasty; PED; Platelet |
author_facet |
Shaban Alizadeh Sahar Balagholi Alireza Baradaran-Rafii Siamak Delfaza-Baher Sare Safi Hamid Safi Rasul Dabbaghi Mozhgan Rezaei Kanavi |
author_sort |
Shaban Alizadeh |
title |
Autologous platelet-rich plasma eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects |
title_short |
Autologous platelet-rich plasma eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects |
title_full |
Autologous platelet-rich plasma eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects |
title_fullStr |
Autologous platelet-rich plasma eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects |
title_full_unstemmed |
Autologous platelet-rich plasma eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects |
title_sort |
autologous platelet-rich plasma eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects |
publisher |
Knowledge E |
series |
Journal of Ophthalmic & Vision Research |
issn |
2008-322X |
publishDate |
2019-01-01 |
description |
Purpose: To investigate whether autologous platelet-rich plasma (PRP) eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects (PEDs).
Methods: A total of 34 eyes with PEDs after keratoplasty (24 penetrating keratoplasty and 10 deep anterior lamellar keratoplasty) that were refractory to conventional medical treatments were treated with PRP eye drops every 3 hours. PRP eye drops were prepared with a low- and high-speed centrifugation method and final platelet counts were 700,000-800,000 plt/μl. The mean treatment duration for complete re-epithelialization was compared with the mean treatment duration of conventionally treated corneal defects before the PRP treatment by paired t-test. The mean treatment duration was also statistically analyzed between age groups, gender, indications for keratoplasty, and types of keratoplasty using analysis of variance (ANOVA).
Results: Treatment with autologous PRP eye drops led to rapid re-epithelialization in all eyes. The mean treatment duration for complete re-epithelialization was 2.47 ± 1.21 weeks, which was significantly shorter than the mean treatment duration of conventionally treated corneal defects before PRP treatment (6.82 ± 1.24 weeks) (P = 0.0001). There was no significant correlation between re-epithelialization time and patients' age, sex, indications for keratoplasty, and techniques of corneal transplantation.
Conclusion: Treatment with autologous PRP eye drops is an effective and reliable approach that accelerates re-epithelialization of post-transplantation PEDs. |
topic |
Corneal Epithelial Defects; Eye Drop; Healing; Keratoplasty; PED; Platelet |
url |
http://www.jovr.org/article.asp?issn=2008-322X;year=2019;volume=14;issue=2;spage=131;epage=135;aulast=Alizadeh |
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