Role of Histamine and Symbiotic Microbiota in Realizing the Allergopathology Risks in the First Months of Life

• Main Authors: L. A. Lityaeva, V. A. Zhirnov, S. Y. Nosyreva
• Format: Article
• Language: Russian
• Published: LLC "Diagnostics and Vaccines" 2019-07-01
• Series: Detskie Infekcii (Moskva)
• Subjects: pregnant womеn; infants; intestinal microbiota; histamine release; allergopathology
• Online Access: https://detinf.elpub.ru/jour/article/view/418

The purpose of research is to designate the significance of histamine and symbiotic microbiota in the development of allergopathology  in the first months of baby’s life.As a result of the study of 80 «mother-child» pairs with a burdened genetic history of allergopathology, it has been found that the intensity of histamine production by intestinal strains in women with intestinal microbiota disorders was significantly higher than that in women without it (2 = 4,6; p = 0,032). It has been revealed that the intensity of the histamine release depends on the severity of intestinal symbiotic microbiota disorders.The correlation between the severity of the gut microbiota disorders and the intensity of histamine release of intestinal strains of mothers with these indicators of their newborns  (rs = 0,761; p < 0,05) has been revealed.The degree of severity of intestinal symbiotic microbiota disorders and the intensity of histamine release the baby’s risk of allergic disease development significantly affect the frequency of gastrointestinal and skin manifestations of allergies (2 > 3,8; p = 0,05).