Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss
Hearing loss: Disruption at the junction A decrease in the levels of connexin proteins at the junctions connecting cells in the inner-ear precedes age-related hearing loss (ARHL) in mice. Loss of hearing in the elderly is a growing problem in ageing populations. Although mutations in genes encoding...
Main Authors: | Shori Tajima, Keiko Danzaki, Katsuhisa Ikeda, Kazusaku Kamiya |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-01-01
|
Series: | Experimental and Molecular Medicine |
Online Access: | https://doi.org/10.1038/s12276-020-0377-1 |
Similar Items
-
Activin/Nodal/TGF-β Pathway Inhibitor Accelerates BMP4-Induced Cochlear Gap Junction Formation During in vitro Differentiation of Embryonic Stem Cells
by: Ichiro Fukunaga, et al.
Published: (2021-04-01) -
Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness.
by: Yoshinobu Kidokoro, et al.
Published: (2014-01-01) -
Generation of two iPSC lines from siblings of a homozygous patient with hearing loss and a heterozygous carrier with normal hearing carrying p.G45E/Y136X mutation in GJB2
by: Ichiro Fukunaga, et al.
Published: (2021-05-01) -
Generation of the induced pluripotent stem cell (hiPSC) line (JUFMDOi004-A) from a patient with hearing loss carrying GJB2 (p.V37I) mutation
by: Ichiro Fukunaga, et al.
Published: (2020-03-01) -
Generation of two induced pluripotent stem cell lines from PBMCs of siblings carrying c.235delC mutation in the GJB2 gene associated with sensorineural hearing loss
by: Ichiro Fukunaga, et al.
Published: (2020-08-01)