Antihepatotoxic effect of isolated chitin from Rhizopus oryzae against paracetamol-induced hepatotoxicity
The present study was aimed at investigating the antihepatotoxic activity of isolated fungal chitin, a natural polysaccharide from Rhizopus oryzae NCIM1009 against paracetamol-induced toxicity in rats. Changes in the levels of biochemical markers of hepatic injury such as serum glutamate oxaloacet...
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Bangladesh Pharmacological Society
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doaj-7645dccb22424b27b1639e6f3bf5ed262020-11-24T21:54:10ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882011-09-016110.3329/bjp.v6i1.8556Antihepatotoxic effect of isolated chitin from Rhizopus oryzae against paracetamol-induced hepatotoxicityAkila Ramanathan0Ramya Kittusamy1Department of Pharmaceutical Biotechnology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil NaduDepartment of Pharmaceutical Biotechnology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu The present study was aimed at investigating the antihepatotoxic activity of isolated fungal chitin, a natural polysaccharide from Rhizopus oryzae NCIM1009 against paracetamol-induced toxicity in rats. Changes in the levels of biochemical markers of hepatic injury such as serum glutamate oxaloacetic transaminase (SGOT), serum glutamic pyuruvic transaminase (SGPT), alkaline phosphatase, bilirubin and total protein were determined in both treated and control group of rats. The effect of fungal chitin was compared with that of silymarin (25 mg/kg). The results showed that paracetamol (750 mg/kg) elevated the levels of biomarkers enzymes. Treatment with fungal chitin (200 mg/kg) brought the marker level near to normal and showed significant hepatoprotective activity. Acute toxicity studies of fungal chitin was carried out and found safe up to 2,000 mg/kg. The isolated fungal chitin was characterized by IR spectroscopy and compared with commercial chitin. https://www.banglajol.info/index.php/BJP/article/view/8556Rhizopus oryzaeFungal chitinParacetamolHepatoprotective |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Akila Ramanathan Ramya Kittusamy |
spellingShingle |
Akila Ramanathan Ramya Kittusamy Antihepatotoxic effect of isolated chitin from Rhizopus oryzae against paracetamol-induced hepatotoxicity Bangladesh Journal of Pharmacology Rhizopus oryzae Fungal chitin Paracetamol Hepatoprotective |
author_facet |
Akila Ramanathan Ramya Kittusamy |
author_sort |
Akila Ramanathan |
title |
Antihepatotoxic effect of isolated chitin from Rhizopus oryzae against paracetamol-induced hepatotoxicity |
title_short |
Antihepatotoxic effect of isolated chitin from Rhizopus oryzae against paracetamol-induced hepatotoxicity |
title_full |
Antihepatotoxic effect of isolated chitin from Rhizopus oryzae against paracetamol-induced hepatotoxicity |
title_fullStr |
Antihepatotoxic effect of isolated chitin from Rhizopus oryzae against paracetamol-induced hepatotoxicity |
title_full_unstemmed |
Antihepatotoxic effect of isolated chitin from Rhizopus oryzae against paracetamol-induced hepatotoxicity |
title_sort |
antihepatotoxic effect of isolated chitin from rhizopus oryzae against paracetamol-induced hepatotoxicity |
publisher |
Bangladesh Pharmacological Society |
series |
Bangladesh Journal of Pharmacology |
issn |
1991-0088 |
publishDate |
2011-09-01 |
description |
The present study was aimed at investigating the antihepatotoxic activity of isolated fungal chitin, a natural polysaccharide from Rhizopus oryzae NCIM1009 against paracetamol-induced toxicity in rats. Changes in the levels of biochemical markers of hepatic injury such as serum glutamate oxaloacetic transaminase (SGOT), serum glutamic pyuruvic transaminase (SGPT), alkaline phosphatase, bilirubin and total protein were determined in both treated and control group of rats. The effect of fungal chitin was compared with that of silymarin (25 mg/kg). The results showed that paracetamol (750 mg/kg) elevated the levels of biomarkers enzymes. Treatment with fungal chitin (200 mg/kg) brought the marker level near to normal and showed significant hepatoprotective activity. Acute toxicity studies of fungal chitin was carried out and found safe up to 2,000 mg/kg. The isolated fungal chitin was characterized by IR spectroscopy and compared with commercial chitin.
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topic |
Rhizopus oryzae Fungal chitin Paracetamol Hepatoprotective |
url |
https://www.banglajol.info/index.php/BJP/article/view/8556 |
work_keys_str_mv |
AT akilaramanathan antihepatotoxiceffectofisolatedchitinfromrhizopusoryzaeagainstparacetamolinducedhepatotoxicity AT ramyakittusamy antihepatotoxiceffectofisolatedchitinfromrhizopusoryzaeagainstparacetamolinducedhepatotoxicity |
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