miR-449a inhibits cell proliferation, migration, and inflammation by regulating high-mobility group box protein 1 and forms a mutual inhibition loop with Yin Yang 1 in rheumatoid arthritis fibroblast-like synoviocytes

miR-449a inhibits cell proliferation, migration, and inflammation by regulating high-mobility group box protein 1 and forms a mutual inhibition loop with Yin Yang 1 in rheumatoid arthritis fibroblast-like synoviocytes

Abstract Background We previously found that high-mobility group box protein 1 (HMGB1) promoted cell proliferation, migration, invasion, and autophagy in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), but little is known about its regulatory mechanism. The aim of this study was to inves...

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Bibliographic Details
Main Authors: Yongsong Cai, Congshan Jiang, Jialin Zhu, Ke Xu, Xiaoyu Ren, Lin Xu, Peijing Hu, Bo Wang, Qiling Yuan, Yuanxu Guo, Jian Sun, Peng Xu, Yusheng Qiu
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Arthritis Research & Therapy
Subjects:
miR-449a
Rheumatoid arthritis
Fibroblast-like synoviocytes
Proliferation
Inflammation
High-mobility group box protein 1
Online Access:http://link.springer.com/article/10.1186/s13075-019-1920-0

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http://link.springer.com/article/10.1186/s13075-019-1920-0

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