Evaluation of the Effect of a Clobetasol Propionate and Nystatin Mouthwash on Recurrent Aphthous Stomataitis
Statement of problem: Recurrent aphthous stomatitis (RAS) is one of the most common diseases affecting human oral mucosa. The etiology of this disease remains unclear; therefore a definitive treatment has not yet been established and corticosteroids might be prescribed to reduce the symptoms associa...
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Tehran University of Medical Sciences
2006-09-01
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doaj-766aa66833854215b4492b2065ed56f52020-11-25T03:37:15ZengTehran University of Medical SciencesJournal of Dentistry of Tehran University of Medical Sciences 2008-21852006-09-0133117121Evaluation of the Effect of a Clobetasol Propionate and Nystatin Mouthwash on Recurrent Aphthous StomataitisA. DarbandiA. GanbariStatement of problem: Recurrent aphthous stomatitis (RAS) is one of the most common diseases affecting human oral mucosa. The etiology of this disease remains unclear; therefore a definitive treatment has not yet been established and corticosteroids might be prescribed to reduce the symptoms associated with RAS.Purpose: The aim of this study was to determine the effects of a mouthwash containing 0.05% clobetasol and nystatin on aphthous ulcers.Materials and Methods: Forty patients with RAS, 18 males and 22 females with an age range of 11-50 years, participated in this double-blind placebo-controlled clinical trial. The subjects were randomly divided into two equal groups. Group A received amouthwash containing 0.05% clobetasol and 100,000 IU/cc nystatin with instructions to rinse with 20 drops for 5 minutes, 3 times daily. Group B (control) received placebo and was asked to follow the same instructions. All symptoms along with possible adverseeffects were measured and recorded during the 2-week study period. Statistical analysis was performed using chi-square and independent paired t-tests.Results: Complete resolution of the lesions and their symptoms was observed in 85% of the participants in group A. Two (10%) patients showed no response to treatment and the symptoms increased in 5% (1 patient). There were no measurable changes in pain or healing time of the ulcers in the control group.Conclusion: The use of the tested mouthwash was found to be a safe and efficacious treatment for RAS of the oral mucosa.http://journals.tums.ac.ir/upload_files/pdf/3362.pdfRecurrent Aphthous Stomatitis (RAS)NystatinClobetasol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A. Darbandi A. Ganbari |
spellingShingle |
A. Darbandi A. Ganbari Evaluation of the Effect of a Clobetasol Propionate and Nystatin Mouthwash on Recurrent Aphthous Stomataitis Journal of Dentistry of Tehran University of Medical Sciences Recurrent Aphthous Stomatitis (RAS) Nystatin Clobetasol |
author_facet |
A. Darbandi A. Ganbari |
author_sort |
A. Darbandi |
title |
Evaluation of the Effect of a Clobetasol Propionate and Nystatin Mouthwash on Recurrent Aphthous Stomataitis |
title_short |
Evaluation of the Effect of a Clobetasol Propionate and Nystatin Mouthwash on Recurrent Aphthous Stomataitis |
title_full |
Evaluation of the Effect of a Clobetasol Propionate and Nystatin Mouthwash on Recurrent Aphthous Stomataitis |
title_fullStr |
Evaluation of the Effect of a Clobetasol Propionate and Nystatin Mouthwash on Recurrent Aphthous Stomataitis |
title_full_unstemmed |
Evaluation of the Effect of a Clobetasol Propionate and Nystatin Mouthwash on Recurrent Aphthous Stomataitis |
title_sort |
evaluation of the effect of a clobetasol propionate and nystatin mouthwash on recurrent aphthous stomataitis |
publisher |
Tehran University of Medical Sciences |
series |
Journal of Dentistry of Tehran University of Medical Sciences |
issn |
2008-2185 |
publishDate |
2006-09-01 |
description |
Statement of problem: Recurrent aphthous stomatitis (RAS) is one of the most common diseases affecting human oral mucosa. The etiology of this disease remains unclear; therefore a definitive treatment has not yet been established and corticosteroids might be prescribed to reduce the symptoms associated with RAS.Purpose: The aim of this study was to determine the effects of a mouthwash containing 0.05% clobetasol and nystatin on aphthous ulcers.Materials and Methods: Forty patients with RAS, 18 males and 22 females with an age range of 11-50 years, participated in this double-blind placebo-controlled clinical trial. The subjects were randomly divided into two equal groups. Group A received amouthwash containing 0.05% clobetasol and 100,000 IU/cc nystatin with instructions to rinse with 20 drops for 5 minutes, 3 times daily. Group B (control) received placebo and was asked to follow the same instructions. All symptoms along with possible adverseeffects were measured and recorded during the 2-week study period. Statistical analysis was performed using chi-square and independent paired t-tests.Results: Complete resolution of the lesions and their symptoms was observed in 85% of the participants in group A. Two (10%) patients showed no response to treatment and the symptoms increased in 5% (1 patient). There were no measurable changes in pain or healing time of the ulcers in the control group.Conclusion: The use of the tested mouthwash was found to be a safe and efficacious treatment for RAS of the oral mucosa. |
topic |
Recurrent Aphthous Stomatitis (RAS) Nystatin Clobetasol |
url |
http://journals.tums.ac.ir/upload_files/pdf/3362.pdf |
work_keys_str_mv |
AT adarbandi evaluationoftheeffectofaclobetasolpropionateandnystatinmouthwashonrecurrentaphthousstomataitis AT aganbari evaluationoftheeffectofaclobetasolpropionateandnystatinmouthwashonrecurrentaphthousstomataitis |
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