Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis
The adrenal glands are able to modulate immune responses through neuroimmunoendocrine interactions and cortisol secretion that could suppress exacerbated inflammation such as in inflammatory bowel disease (IBD). Therefore, here we evaluated the role of these glands in experimental colitis induced by...
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Series: | Mediators of Inflammation |
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doaj-76718e5ff07140418ef4974a824e9f012020-11-24T23:01:12ZengHindawi LimitedMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/49363704936370Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental ColitisPatrícia Reis de Souza0Helioswilton Sales-Campos1Paulo José Basso2Viviani Nardini3Angelica Silva4Fernanda Banquieri5Vanessa Beatriz Freitas Alves6Javier Emílio Lazo Chica7Auro Nomizo8Cristina Ribeiro de Barros Cardoso9Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, SP, BrazilDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, SP, BrazilDepartamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, SP, BrazilDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, SP, BrazilDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, SP, BrazilDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, SP, BrazilDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, SP, BrazilInstituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro, Uberaba, MG, BrazilDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, SP, BrazilDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, SP, BrazilThe adrenal glands are able to modulate immune responses through neuroimmunoendocrine interactions and cortisol secretion that could suppress exacerbated inflammation such as in inflammatory bowel disease (IBD). Therefore, here we evaluated the role of these glands in experimental colitis induced by 3% dextran sulfate sodium (DSS) in C57BL/6 mice subjected to adrenalectomy, with or without glucocorticoid (GC) replacement. Mice succumbed to colitis without adrenals with a higher clinical score and augmented systemic levels of IL-6 and lower LPS. Furthermore, adrenalectomy negatively modulated systemic regulatory markers. The absence of adrenals resulted in augmented tolerogenic lamina propria dendritic cells but no compensatory local production of corticosterone and decreased mucosal inflammation associated with increased IFN-γ and FasL in the intestine. To clarify the importance of GC in this scenario, GC replacement in adrenalectomized mice restored different markers to the same degree of that observed in DSS group. Finally, this is the first time that adrenal-derived hormones, especially GC, were associated with the differential local modulation of the gut infiltrate, also pointing to a relationship between adrenalectomy and the modulation of systemic regulatory markers. These findings may elucidate some neuroimmunoendocrine mechanisms that dictate colitis outcome.http://dx.doi.org/10.1155/2016/4936370 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Patrícia Reis de Souza Helioswilton Sales-Campos Paulo José Basso Viviani Nardini Angelica Silva Fernanda Banquieri Vanessa Beatriz Freitas Alves Javier Emílio Lazo Chica Auro Nomizo Cristina Ribeiro de Barros Cardoso |
spellingShingle |
Patrícia Reis de Souza Helioswilton Sales-Campos Paulo José Basso Viviani Nardini Angelica Silva Fernanda Banquieri Vanessa Beatriz Freitas Alves Javier Emílio Lazo Chica Auro Nomizo Cristina Ribeiro de Barros Cardoso Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis Mediators of Inflammation |
author_facet |
Patrícia Reis de Souza Helioswilton Sales-Campos Paulo José Basso Viviani Nardini Angelica Silva Fernanda Banquieri Vanessa Beatriz Freitas Alves Javier Emílio Lazo Chica Auro Nomizo Cristina Ribeiro de Barros Cardoso |
author_sort |
Patrícia Reis de Souza |
title |
Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis |
title_short |
Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis |
title_full |
Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis |
title_fullStr |
Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis |
title_full_unstemmed |
Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis |
title_sort |
adrenal-derived hormones differentially modulate intestinal immunity in experimental colitis |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2016-01-01 |
description |
The adrenal glands are able to modulate immune responses through neuroimmunoendocrine interactions and cortisol secretion that could suppress exacerbated inflammation such as in inflammatory bowel disease (IBD). Therefore, here we evaluated the role of these glands in experimental colitis induced by 3% dextran sulfate sodium (DSS) in C57BL/6 mice subjected to adrenalectomy, with or without glucocorticoid (GC) replacement. Mice succumbed to colitis without adrenals with a higher clinical score and augmented systemic levels of IL-6 and lower LPS. Furthermore, adrenalectomy negatively modulated systemic regulatory markers. The absence of adrenals resulted in augmented tolerogenic lamina propria dendritic cells but no compensatory local production of corticosterone and decreased mucosal inflammation associated with increased IFN-γ and FasL in the intestine. To clarify the importance of GC in this scenario, GC replacement in adrenalectomized mice restored different markers to the same degree of that observed in DSS group. Finally, this is the first time that adrenal-derived hormones, especially GC, were associated with the differential local modulation of the gut infiltrate, also pointing to a relationship between adrenalectomy and the modulation of systemic regulatory markers. These findings may elucidate some neuroimmunoendocrine mechanisms that dictate colitis outcome. |
url |
http://dx.doi.org/10.1155/2016/4936370 |
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