LAA1 HEMODYNAMIC AND STRUCTURAL ARTERIAL PARAMETERS’ ASSOCIATION WITH INTERINDIVIDUAL VARIATIONS OF BODY MASS INDEX IN CHILDHOOD AND ADOLESCENCE

• Main Authors: Victoria Garcia, Santiago Curcio, Agustina Zinoveev, Gustavo Giachetto, Pedro Chiesa, Daniel Bia, Yanina Zócalo
• Format: Article
• Language: English
• Published: Atlantis Press 2017-12-01
• Series: Artery Research
• Online Access: https://www.atlantis-press.com/article/125930180/view

Background: Several works analyze arterial parameters’ (stiffness levels, wall thickness, etc.) association with variations of body mass index (BMI) in pediatric populations. However, none integrate different arterial parameters as comparable continuous (standardized) variables, in order to assess their association with standardized (age- and sex-independent) BMI scores (zBMI). Aims: To analyze the association of standardized arterial parameters with interindividual variations of zBMI. Methods: 609 children and adolescents (mean age/range: 12/4–18 years, 45% females) were studied. Body mass index (BMI) was calculated. zBMI scores were derived from population-based tables. Non-invasive arterial assessment was performed: oscillometric measurements of peripheral systolic (pSBP), diastolic (pDBP) and pulse pressure (pPP), and central (applanation tonometry) systolic (cSBP), diastolic (cDBP) and pulse pressure (cPP); ultrasonographic measurements of common carotid (CCA), femoral (CFA) and brachial (BA) diastolic diameters (DD), and CCA intima-media thickness (cIMT). Arterial elastic moduli (EM) were calculated. Arterial parameters were standardized with equations derived from a reference population (no cardiovascular risk factor exposure). Simple linear regression models were obtained for the different standardized arterial parameters with zBMI as the independent variable. Statistical threshold was 0.05. Results: We found a positive and significant association between zBMI and standardized pSBP (β = 0.210), pPP (β = 0.150), cSBP (β = 0.204) and cPP (β = 0.188), CCA DD (β = 0.145), FCA (β = 0.143), BA (β = 0.210), cIMT (β = 0.135), and CCA EM (β = 0.117). Conclusions: Higher zBMI associated higher standardized arterial blood pressure, stiffness levels, diameters and thickness. Hemodynamic parameters presented the stronger associations with zBMI variations.