Cerebral Regional Homogeneity Alternation of Pregnant Women With Antenatal Depression During the Pandemic
Purpose: The COVID-19 epidemic has been a threat to the health of people all over the world. Various precautions during COVID-19 in China have kept a large number of people in isolation, and this has inconvenienced and placed enormous stress on pregnant women. Pregnant women are more likely to suffe...
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doaj-767fe0c8d4294509b4ffa1ce8c3fccf42021-04-20T05:01:14ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-04-011210.3389/fpsyt.2021.627871627871Cerebral Regional Homogeneity Alternation of Pregnant Women With Antenatal Depression During the PandemicBochao Cheng0Yajing Meng1Yushan Zhou2Jinrong Li3Jianguang Zeng4Xi Tan5Kaiyou Zhang6Ya Luo7Yan Zhang8Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, ChinaSchool of Economics and Business Administration, Chongqing University, Chongqing, ChinaDepartment of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Clinical Laboratory, West China Second Hospital, Sichuan University, Chengdu, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Gynecology and Obstetrics, Wuxi Maternal and Child Health Hospital, The Affiliated Hospital of Nanjing Medical University, Wuxi, ChinaPurpose: The COVID-19 epidemic has been a threat to the health of people all over the world. Various precautions during COVID-19 in China have kept a large number of people in isolation, and this has inconvenienced and placed enormous stress on pregnant women. Pregnant women are more likely to suffer from antenatal depression (ANDP) with social isolation or low social support. This research aims to investigate the neurobiological mechanisms underlying ANDP, which impedes early detection and intervention in this disorder.Methods: A total of 43 singleton pregnant women who experienced isolation were recruited, including 21 treatment-naïve ANDP patients and 22 healthy pregnant women (HPW). To explore the intrinsic cerebral activity alternations in ANDP using resting-state functional MRI (rsfMRI), we assessed the local regional homogeneity (ReHo) differences in two groups using the voxel-based whole-brain analysis. The correlation between the regional functional abnormalities and clinical variables in ANDP patients was also examined.Results: Compared with HPW, ANDP patients showed decreased ReHo in the left dorsolateral prefrontal cortex, right insular and the cluster coving the right ventral temporal cortex (VTC), amygdala (AMG), and hippocampus (HIP). The Edinburgh Postnatal Depression Scale (EPDS) scores of ANDP patients negatively correlated with the ReHo in the right VTC, AMG, and HIP.Conclusion: Elucidating the neurobiological features of ANDP patients during COVID-19 is crucial for evolving adequate methods for early diagnosis, precaution, and intervention in a future epidemic.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.627871/fullCOVID-19antenatal depressionresting-state fMRIReHopregnant womensocial isolation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bochao Cheng Yajing Meng Yushan Zhou Jinrong Li Jianguang Zeng Xi Tan Kaiyou Zhang Ya Luo Yan Zhang |
spellingShingle |
Bochao Cheng Yajing Meng Yushan Zhou Jinrong Li Jianguang Zeng Xi Tan Kaiyou Zhang Ya Luo Yan Zhang Cerebral Regional Homogeneity Alternation of Pregnant Women With Antenatal Depression During the Pandemic Frontiers in Psychiatry COVID-19 antenatal depression resting-state fMRI ReHo pregnant women social isolation |
author_facet |
Bochao Cheng Yajing Meng Yushan Zhou Jinrong Li Jianguang Zeng Xi Tan Kaiyou Zhang Ya Luo Yan Zhang |
author_sort |
Bochao Cheng |
title |
Cerebral Regional Homogeneity Alternation of Pregnant Women With Antenatal Depression During the Pandemic |
title_short |
Cerebral Regional Homogeneity Alternation of Pregnant Women With Antenatal Depression During the Pandemic |
title_full |
Cerebral Regional Homogeneity Alternation of Pregnant Women With Antenatal Depression During the Pandemic |
title_fullStr |
Cerebral Regional Homogeneity Alternation of Pregnant Women With Antenatal Depression During the Pandemic |
title_full_unstemmed |
Cerebral Regional Homogeneity Alternation of Pregnant Women With Antenatal Depression During the Pandemic |
title_sort |
cerebral regional homogeneity alternation of pregnant women with antenatal depression during the pandemic |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2021-04-01 |
description |
Purpose: The COVID-19 epidemic has been a threat to the health of people all over the world. Various precautions during COVID-19 in China have kept a large number of people in isolation, and this has inconvenienced and placed enormous stress on pregnant women. Pregnant women are more likely to suffer from antenatal depression (ANDP) with social isolation or low social support. This research aims to investigate the neurobiological mechanisms underlying ANDP, which impedes early detection and intervention in this disorder.Methods: A total of 43 singleton pregnant women who experienced isolation were recruited, including 21 treatment-naïve ANDP patients and 22 healthy pregnant women (HPW). To explore the intrinsic cerebral activity alternations in ANDP using resting-state functional MRI (rsfMRI), we assessed the local regional homogeneity (ReHo) differences in two groups using the voxel-based whole-brain analysis. The correlation between the regional functional abnormalities and clinical variables in ANDP patients was also examined.Results: Compared with HPW, ANDP patients showed decreased ReHo in the left dorsolateral prefrontal cortex, right insular and the cluster coving the right ventral temporal cortex (VTC), amygdala (AMG), and hippocampus (HIP). The Edinburgh Postnatal Depression Scale (EPDS) scores of ANDP patients negatively correlated with the ReHo in the right VTC, AMG, and HIP.Conclusion: Elucidating the neurobiological features of ANDP patients during COVID-19 is crucial for evolving adequate methods for early diagnosis, precaution, and intervention in a future epidemic. |
topic |
COVID-19 antenatal depression resting-state fMRI ReHo pregnant women social isolation |
url |
https://www.frontiersin.org/articles/10.3389/fpsyt.2021.627871/full |
work_keys_str_mv |
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