Synthesis of porous silica hollow spheres using sacrificial template for drug delivery applications
In this work, we report on the synthesis of SiO2 hollow spheres using carbon nanospheres as the sacrificial template by hydrothermal method. The synthesized substrates are in a spherical morphology and uniform size distribution. The effects of hydrothermal process, concentration and the reaction tem...
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Growing Science
2014-06-01
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Online Access: | http://www.growingscience.com/ccl/online/ccl_2014_12.pdf |
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doaj-76876c9a5d4048c098068839f31b2cbc2020-11-25T01:21:21ZengGrowing ScienceCurrent Chemistry Letters1927-72961927-730X2014-06-013314114610.5267/j.ccl.2014.5.005Synthesis of porous silica hollow spheres using sacrificial template for drug delivery applications Rasoul SafdariShahrara AfsharAlireza Khosravi In this work, we report on the synthesis of SiO2 hollow spheres using carbon nanospheres as the sacrificial template by hydrothermal method. The synthesized substrates are in a spherical morphology and uniform size distribution. The effects of hydrothermal process, concentration and the reaction temperature were optimized during synthesis of carbon nanospheres. Infrared spectroscopy (IR), and scanning electronic microscopy (SEM) methods were used for identification of the synthesized products. The synthesized SiO2 nanospheres were used as drug carrier to investigate in vitro release behavior of monoterpenic phenol isomers, carvacrol and thymol, in simulated body fluid (SBF). Ultraviolet-visible spectroscopy (UV-vis) method was carried out to determine the amount of the drugs entrapped in the carrier. The results indicated that SiO2 nanospheres have high ability to adsorb the drugs and there is no need for adjusting the pH during the adsorption process. The drug release profile shows a three stages pattern and indicates a delayed release action.http://www.growingscience.com/ccl/online/ccl_2014_12.pdfSiO2 hallow sphereDrug deliverySacrificial template |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rasoul Safdari Shahrara Afshar Alireza Khosravi |
spellingShingle |
Rasoul Safdari Shahrara Afshar Alireza Khosravi Synthesis of porous silica hollow spheres using sacrificial template for drug delivery applications Current Chemistry Letters SiO2 hallow sphere Drug delivery Sacrificial template |
author_facet |
Rasoul Safdari Shahrara Afshar Alireza Khosravi |
author_sort |
Rasoul Safdari |
title |
Synthesis of porous silica hollow spheres using sacrificial template for drug delivery applications |
title_short |
Synthesis of porous silica hollow spheres using sacrificial template for drug delivery applications |
title_full |
Synthesis of porous silica hollow spheres using sacrificial template for drug delivery applications |
title_fullStr |
Synthesis of porous silica hollow spheres using sacrificial template for drug delivery applications |
title_full_unstemmed |
Synthesis of porous silica hollow spheres using sacrificial template for drug delivery applications |
title_sort |
synthesis of porous silica hollow spheres using sacrificial template for drug delivery applications |
publisher |
Growing Science |
series |
Current Chemistry Letters |
issn |
1927-7296 1927-730X |
publishDate |
2014-06-01 |
description |
In this work, we report on the synthesis of SiO2 hollow spheres using carbon nanospheres as the sacrificial template by hydrothermal method. The synthesized substrates are in a spherical morphology and uniform size distribution. The effects of hydrothermal process, concentration and the reaction temperature were optimized during synthesis of carbon nanospheres. Infrared spectroscopy (IR), and scanning electronic microscopy (SEM) methods were used for identification of the synthesized products. The synthesized SiO2 nanospheres were used as drug carrier to investigate in vitro release behavior of monoterpenic phenol isomers, carvacrol and thymol, in simulated body fluid (SBF). Ultraviolet-visible spectroscopy (UV-vis) method was carried out to determine the amount of the drugs entrapped in the carrier. The results indicated that SiO2 nanospheres have high ability to adsorb the drugs and there is no need for adjusting the pH during the adsorption process. The drug release profile shows a three stages pattern and indicates a delayed release action. |
topic |
SiO2 hallow sphere Drug delivery Sacrificial template |
url |
http://www.growingscience.com/ccl/online/ccl_2014_12.pdf |
work_keys_str_mv |
AT rasoulsafdari synthesisofporoussilicahollowspheresusingsacrificialtemplatefordrugdeliveryapplications AT shahraraafshar synthesisofporoussilicahollowspheresusingsacrificialtemplatefordrugdeliveryapplications AT alirezakhosravi synthesisofporoussilicahollowspheresusingsacrificialtemplatefordrugdeliveryapplications |
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1725130742482075648 |