Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study
CONTEXT AND OBJECTIVE: Bacterial vaginosis has been associated with prematurity and other perinatal complications. However, the efficacy of the treatment for preventing such complications has not yet been well established. The objective of this study was to evaluate the impact of treatment for bacte...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Associação Paulista de Medicina
|
Series: | São Paulo Medical Journal |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802005000300004&lng=en&tlng=en |
id |
doaj-768d6639bf5242ccb3077ff902852c6a |
---|---|
record_format |
Article |
spelling |
doaj-768d6639bf5242ccb3077ff902852c6a2020-11-25T01:38:23ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460123310811210.1590/S1516-31802005000300004S1516-31802005000300004Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort studyRodrigo Pauperio Soares de Camargo0José Antonio Simões1José Guilherme Cecatti2Valéria Moraes Nader Alves3Sebastian Faro4Universidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual de CampinasThe University of TexasCONTEXT AND OBJECTIVE: Bacterial vaginosis has been associated with prematurity and other perinatal complications. However, the efficacy of the treatment for preventing such complications has not yet been well established. The objective of this study was to evaluate the impact of treatment for bacterial vaginosis on a low-risk population of Brazilian pregnant women, in order to prevent prematurity and other perinatal complications. DESIGN AND SETTING: Observational retrospective cohort study, at the Obstetric and Gynecology Department, Universidade Estadual de Campinas (Unicamp). METHODS: Vaginal bacterioscopy results from 785 low-risk pregnant women were studied. Three different groups of women were identified: 580 without bacterial vaginosis during pregnancy, 134 with bacterial vaginosis treated using imidazoles (metronidazole, tinidazole, or secnidazole) during pregnancy, and 71 with bacterial vaginosis not treated during pregnancy. The diagnosis of bacterial vaginosis was based on Nugent's criteria, from the vaginal bacterioscopy performed during the first prenatal care visit. RESULTS: The frequency of prematurity was 5.5% among the women without bacterial vaginosis, 22.5% among those with untreated bacterial vaginosis and 3.7% among those with treated bacterial vaginosis. The risk ratios for perinatal complications were significantly higher in the group with untreated bacterial vaginosis: premature rupture of membranes, 7.5 (95% CI: 1.9-34.9); preterm labor, 3.4 (95% CI: 1.4-8.1); preterm birth, 6.0 (95% CI: 1.9-19.7); and low birth weight, 4.2 (95% CI: 1.2-14.3). CONCLUSION: The treatment of bacterial vaginosis significantly reduced the rates of prematurity and other perinatal complications among these low-risk Brazilian pregnant women, regardless of the history of previous preterm delivery.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802005000300004&lng=en&tlng=enBacterial vaginosisPregnancyPremature infantPerinatal carePregnancy complications |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rodrigo Pauperio Soares de Camargo José Antonio Simões José Guilherme Cecatti Valéria Moraes Nader Alves Sebastian Faro |
spellingShingle |
Rodrigo Pauperio Soares de Camargo José Antonio Simões José Guilherme Cecatti Valéria Moraes Nader Alves Sebastian Faro Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study São Paulo Medical Journal Bacterial vaginosis Pregnancy Premature infant Perinatal care Pregnancy complications |
author_facet |
Rodrigo Pauperio Soares de Camargo José Antonio Simões José Guilherme Cecatti Valéria Moraes Nader Alves Sebastian Faro |
author_sort |
Rodrigo Pauperio Soares de Camargo |
title |
Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study |
title_short |
Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study |
title_full |
Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study |
title_fullStr |
Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study |
title_full_unstemmed |
Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study |
title_sort |
impact of treatment for bacterial vaginosis on prematurity among brazilian pregnant women: a retrospective cohort study |
publisher |
Associação Paulista de Medicina |
series |
São Paulo Medical Journal |
issn |
1806-9460 |
description |
CONTEXT AND OBJECTIVE: Bacterial vaginosis has been associated with prematurity and other perinatal complications. However, the efficacy of the treatment for preventing such complications has not yet been well established. The objective of this study was to evaluate the impact of treatment for bacterial vaginosis on a low-risk population of Brazilian pregnant women, in order to prevent prematurity and other perinatal complications. DESIGN AND SETTING: Observational retrospective cohort study, at the Obstetric and Gynecology Department, Universidade Estadual de Campinas (Unicamp). METHODS: Vaginal bacterioscopy results from 785 low-risk pregnant women were studied. Three different groups of women were identified: 580 without bacterial vaginosis during pregnancy, 134 with bacterial vaginosis treated using imidazoles (metronidazole, tinidazole, or secnidazole) during pregnancy, and 71 with bacterial vaginosis not treated during pregnancy. The diagnosis of bacterial vaginosis was based on Nugent's criteria, from the vaginal bacterioscopy performed during the first prenatal care visit. RESULTS: The frequency of prematurity was 5.5% among the women without bacterial vaginosis, 22.5% among those with untreated bacterial vaginosis and 3.7% among those with treated bacterial vaginosis. The risk ratios for perinatal complications were significantly higher in the group with untreated bacterial vaginosis: premature rupture of membranes, 7.5 (95% CI: 1.9-34.9); preterm labor, 3.4 (95% CI: 1.4-8.1); preterm birth, 6.0 (95% CI: 1.9-19.7); and low birth weight, 4.2 (95% CI: 1.2-14.3). CONCLUSION: The treatment of bacterial vaginosis significantly reduced the rates of prematurity and other perinatal complications among these low-risk Brazilian pregnant women, regardless of the history of previous preterm delivery. |
topic |
Bacterial vaginosis Pregnancy Premature infant Perinatal care Pregnancy complications |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802005000300004&lng=en&tlng=en |
work_keys_str_mv |
AT rodrigopauperiosoaresdecamargo impactoftreatmentforbacterialvaginosisonprematurityamongbrazilianpregnantwomenaretrospectivecohortstudy AT joseantoniosimoes impactoftreatmentforbacterialvaginosisonprematurityamongbrazilianpregnantwomenaretrospectivecohortstudy AT joseguilhermececatti impactoftreatmentforbacterialvaginosisonprematurityamongbrazilianpregnantwomenaretrospectivecohortstudy AT valeriamoraesnaderalves impactoftreatmentforbacterialvaginosisonprematurityamongbrazilianpregnantwomenaretrospectivecohortstudy AT sebastianfaro impactoftreatmentforbacterialvaginosisonprematurityamongbrazilianpregnantwomenaretrospectivecohortstudy |
_version_ |
1725054147126886400 |