Comparison of bone and renal effects in HIV-infected adults switching to abacavir or tenofovir based therapy in a randomized trial.
Our objective was to compare the bone and renal effects among HIV-infected patients randomized to abacavir or tenofovir-based combination anti-retroviral therapy.In an open-label randomized trial, HIV-infected patients were randomized to switch from zidovudine/lamivudine (AZT/3TC) to abacavir/lamivu...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3315554?pdf=render |
id |
doaj-768f1590379745028d985e9d7bfd8d7f |
---|---|
record_format |
Article |
spelling |
doaj-768f1590379745028d985e9d7bfd8d7f2020-11-24T22:11:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0173e3244510.1371/journal.pone.0032445Comparison of bone and renal effects in HIV-infected adults switching to abacavir or tenofovir based therapy in a randomized trial.Thomas A RasmussenDanny JensenMartin TolstrupUlla S NielsenErland J ErlandsenHenrik BirnLars ØstergaardBente L LangdahlAlex L LaursenOur objective was to compare the bone and renal effects among HIV-infected patients randomized to abacavir or tenofovir-based combination anti-retroviral therapy.In an open-label randomized trial, HIV-infected patients were randomized to switch from zidovudine/lamivudine (AZT/3TC) to abacavir/lamivudine (ABC/3TC) or tenofovir/emtricitabine (TDF/FTC). We measured bone mass density (BMD) and bone turnover biomarkers (osteocalcin, osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), alkaline phosphatase, type I collagen cross-linked C-telopeptide (CTx), and osteoprotegerin). We assessed renal function by estimated creatinine clearance, plasma cystatin C, and urinary levels of creatinine, albumin, cystatin C, and neutrophil gelatinase-associated lipocalin (NGAL). The changes from baseline in BMD and renal and bone biomarkers were compared across study arms.Of 40 included patients, 35 completed 48 weeks of randomized therapy and follow up. BMD was measured in 33, 26, and 27 patients at baseline, week 24, and week 48, respectively. In TDF/FTC-treated patients we observed significant reductions from baseline in hip and lumbar spine BMD at week 24 (-1.8% and -2.5%) and week 48 (-2.1% and -2.1%), whereas BMD was stable in patients in the ABC/3TC arm. The changes from baseline in BMD were significantly different between study arms. All bone turnover biomarkers except osteoprotegerin increased in the TDF/FTC arm compared with the ABC/3TC arm, but early changes did not predict subsequent loss of BMD. Renal function parameters were similar between study arms although a small increase in NGAL was detected among TDF-treated patients.Switching to TDF/FTC-based therapy led to decreases in BMD and increases in bone turnover markers compared with ABC/3TC-based treatment. No major difference in renal function was observed.Clinicaltrials.gov NCT00647244.http://europepmc.org/articles/PMC3315554?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thomas A Rasmussen Danny Jensen Martin Tolstrup Ulla S Nielsen Erland J Erlandsen Henrik Birn Lars Østergaard Bente L Langdahl Alex L Laursen |
spellingShingle |
Thomas A Rasmussen Danny Jensen Martin Tolstrup Ulla S Nielsen Erland J Erlandsen Henrik Birn Lars Østergaard Bente L Langdahl Alex L Laursen Comparison of bone and renal effects in HIV-infected adults switching to abacavir or tenofovir based therapy in a randomized trial. PLoS ONE |
author_facet |
Thomas A Rasmussen Danny Jensen Martin Tolstrup Ulla S Nielsen Erland J Erlandsen Henrik Birn Lars Østergaard Bente L Langdahl Alex L Laursen |
author_sort |
Thomas A Rasmussen |
title |
Comparison of bone and renal effects in HIV-infected adults switching to abacavir or tenofovir based therapy in a randomized trial. |
title_short |
Comparison of bone and renal effects in HIV-infected adults switching to abacavir or tenofovir based therapy in a randomized trial. |
title_full |
Comparison of bone and renal effects in HIV-infected adults switching to abacavir or tenofovir based therapy in a randomized trial. |
title_fullStr |
Comparison of bone and renal effects in HIV-infected adults switching to abacavir or tenofovir based therapy in a randomized trial. |
title_full_unstemmed |
Comparison of bone and renal effects in HIV-infected adults switching to abacavir or tenofovir based therapy in a randomized trial. |
title_sort |
comparison of bone and renal effects in hiv-infected adults switching to abacavir or tenofovir based therapy in a randomized trial. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
Our objective was to compare the bone and renal effects among HIV-infected patients randomized to abacavir or tenofovir-based combination anti-retroviral therapy.In an open-label randomized trial, HIV-infected patients were randomized to switch from zidovudine/lamivudine (AZT/3TC) to abacavir/lamivudine (ABC/3TC) or tenofovir/emtricitabine (TDF/FTC). We measured bone mass density (BMD) and bone turnover biomarkers (osteocalcin, osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), alkaline phosphatase, type I collagen cross-linked C-telopeptide (CTx), and osteoprotegerin). We assessed renal function by estimated creatinine clearance, plasma cystatin C, and urinary levels of creatinine, albumin, cystatin C, and neutrophil gelatinase-associated lipocalin (NGAL). The changes from baseline in BMD and renal and bone biomarkers were compared across study arms.Of 40 included patients, 35 completed 48 weeks of randomized therapy and follow up. BMD was measured in 33, 26, and 27 patients at baseline, week 24, and week 48, respectively. In TDF/FTC-treated patients we observed significant reductions from baseline in hip and lumbar spine BMD at week 24 (-1.8% and -2.5%) and week 48 (-2.1% and -2.1%), whereas BMD was stable in patients in the ABC/3TC arm. The changes from baseline in BMD were significantly different between study arms. All bone turnover biomarkers except osteoprotegerin increased in the TDF/FTC arm compared with the ABC/3TC arm, but early changes did not predict subsequent loss of BMD. Renal function parameters were similar between study arms although a small increase in NGAL was detected among TDF-treated patients.Switching to TDF/FTC-based therapy led to decreases in BMD and increases in bone turnover markers compared with ABC/3TC-based treatment. No major difference in renal function was observed.Clinicaltrials.gov NCT00647244. |
url |
http://europepmc.org/articles/PMC3315554?pdf=render |
work_keys_str_mv |
AT thomasarasmussen comparisonofboneandrenaleffectsinhivinfectedadultsswitchingtoabacavirortenofovirbasedtherapyinarandomizedtrial AT dannyjensen comparisonofboneandrenaleffectsinhivinfectedadultsswitchingtoabacavirortenofovirbasedtherapyinarandomizedtrial AT martintolstrup comparisonofboneandrenaleffectsinhivinfectedadultsswitchingtoabacavirortenofovirbasedtherapyinarandomizedtrial AT ullasnielsen comparisonofboneandrenaleffectsinhivinfectedadultsswitchingtoabacavirortenofovirbasedtherapyinarandomizedtrial AT erlandjerlandsen comparisonofboneandrenaleffectsinhivinfectedadultsswitchingtoabacavirortenofovirbasedtherapyinarandomizedtrial AT henrikbirn comparisonofboneandrenaleffectsinhivinfectedadultsswitchingtoabacavirortenofovirbasedtherapyinarandomizedtrial AT larsøstergaard comparisonofboneandrenaleffectsinhivinfectedadultsswitchingtoabacavirortenofovirbasedtherapyinarandomizedtrial AT bentellangdahl comparisonofboneandrenaleffectsinhivinfectedadultsswitchingtoabacavirortenofovirbasedtherapyinarandomizedtrial AT alexllaursen comparisonofboneandrenaleffectsinhivinfectedadultsswitchingtoabacavirortenofovirbasedtherapyinarandomizedtrial |
_version_ |
1725805728319406080 |