Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium
Abstract Objective To identify possible socio-demographic and clinical factors associated with Good Outcome (GO) as compared with Poor Outcome (PO) in adult patients diagnosed with Bipolar Disorder (BD) who received long-term treatment with lithium. Methods A comprehensive search of major electronic...
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doaj-7690168f05004694821251aacd75c9272020-12-20T12:13:57ZengSpringerOpenInternational Journal of Bipolar Disorders2194-75112020-12-018111310.1186/s40345-020-00203-3Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithiumDiane Grillault Laroche0Bruno Etain1Emanuel Severus2Jan Scott3Frank Bellivier4On behalf of the ISBD-IGSLI Joint Task Force on Lithium TreatmentINSERM U1144 – Optimisation Thérapeutique en Neuropsychopharmacologie, Université de Paris DescartesINSERM U1144 – Optimisation Thérapeutique en Neuropsychopharmacologie, Université de Paris DescartesDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU DresdenFaculté de Médecine, Université de ParisINSERM U1144 – Optimisation Thérapeutique en Neuropsychopharmacologie, Université de Paris DescartesAbstract Objective To identify possible socio-demographic and clinical factors associated with Good Outcome (GO) as compared with Poor Outcome (PO) in adult patients diagnosed with Bipolar Disorder (BD) who received long-term treatment with lithium. Methods A comprehensive search of major electronic databases was performed to identify relevant studies that included adults patients (18 years or older) with a diagnosis of BD and reported sociodemographic and/or clinical variables associated with treatment response and/or with illness outcome during long-term treatment to lithium (> = 6 months). The quality of the studies was scored using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies from the National Institute of Health. Results Following review, 34 publications (from 31 independent datasets) were eligible for inclusion in this review. Most of them (n = 25) used a retrospective design. Only 11 studies were graded as good or borderline good quality. Forty-three potential predictors of outcome to lithium were identified. Four factors were associated with PO to lithium: alcohol use disorder; personality disorders; higher lifetime number of hospital admissions and rapid cycling pattern. Two factors were associated with GO in patients treated with lithium: good social support and episodic evolution of BD. However, when the synthesis of findings was limited to the highest (good or borderline good) quality studies (11 studies), only higher lifetime number of hospitalization admissions remained associated with PO to lithium and no associations remained for GO to lithium. Conclusion Despite decades of research on lithium and its clinical use, besides lifetime number of hospital admissions, no factor being consistently associated with GO or PO to lithium was identified. Hence, there remains a substantial gap in our understanding of predictors of outcome of lithium treatment indicating there is a need of high quality research on large representative samples.https://doi.org/10.1186/s40345-020-00203-3Bipolar disorderLithiumResponsePredictionManiaDepression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diane Grillault Laroche Bruno Etain Emanuel Severus Jan Scott Frank Bellivier On behalf of the ISBD-IGSLI Joint Task Force on Lithium Treatment |
spellingShingle |
Diane Grillault Laroche Bruno Etain Emanuel Severus Jan Scott Frank Bellivier On behalf of the ISBD-IGSLI Joint Task Force on Lithium Treatment Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium International Journal of Bipolar Disorders Bipolar disorder Lithium Response Prediction Mania Depression |
author_facet |
Diane Grillault Laroche Bruno Etain Emanuel Severus Jan Scott Frank Bellivier On behalf of the ISBD-IGSLI Joint Task Force on Lithium Treatment |
author_sort |
Diane Grillault Laroche |
title |
Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium |
title_short |
Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium |
title_full |
Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium |
title_fullStr |
Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium |
title_full_unstemmed |
Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium |
title_sort |
socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the isbd/igsli task force on treatment with lithium |
publisher |
SpringerOpen |
series |
International Journal of Bipolar Disorders |
issn |
2194-7511 |
publishDate |
2020-12-01 |
description |
Abstract Objective To identify possible socio-demographic and clinical factors associated with Good Outcome (GO) as compared with Poor Outcome (PO) in adult patients diagnosed with Bipolar Disorder (BD) who received long-term treatment with lithium. Methods A comprehensive search of major electronic databases was performed to identify relevant studies that included adults patients (18 years or older) with a diagnosis of BD and reported sociodemographic and/or clinical variables associated with treatment response and/or with illness outcome during long-term treatment to lithium (> = 6 months). The quality of the studies was scored using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies from the National Institute of Health. Results Following review, 34 publications (from 31 independent datasets) were eligible for inclusion in this review. Most of them (n = 25) used a retrospective design. Only 11 studies were graded as good or borderline good quality. Forty-three potential predictors of outcome to lithium were identified. Four factors were associated with PO to lithium: alcohol use disorder; personality disorders; higher lifetime number of hospital admissions and rapid cycling pattern. Two factors were associated with GO in patients treated with lithium: good social support and episodic evolution of BD. However, when the synthesis of findings was limited to the highest (good or borderline good) quality studies (11 studies), only higher lifetime number of hospitalization admissions remained associated with PO to lithium and no associations remained for GO to lithium. Conclusion Despite decades of research on lithium and its clinical use, besides lifetime number of hospital admissions, no factor being consistently associated with GO or PO to lithium was identified. Hence, there remains a substantial gap in our understanding of predictors of outcome of lithium treatment indicating there is a need of high quality research on large representative samples. |
topic |
Bipolar disorder Lithium Response Prediction Mania Depression |
url |
https://doi.org/10.1186/s40345-020-00203-3 |
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