Gastroprotective effect of soluble dietary fibres from yellow passion fruit (Passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in rats
Yellow passion fruit peel (PFP) is considered an important source of dietary fibre (DF) and its consumption has been associated with health benefits in metabolic and gut disturbs. This work aimed to characterize the chemical structure of soluble DF (SDF) from PFP and evaluate its gastroprotective ac...
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doaj-769a6f24c53548a084f0959aa21ffc8a2021-04-30T07:15:45ZengElsevierJournal of Functional Foods1756-46462019-03-0154552558Gastroprotective effect of soluble dietary fibres from yellow passion fruit (Passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in ratsKahlile Youssef Abboud0Bruna Barbosa da Luz1Jorge Luiz Dallazen2Maria Fernanda de Paula Werner3Cinthia Baú Betim Cazarin4Mário Roberto Maróstica Junior5Marcello Iacomini6Lucimara M.C. Cordeiro7Department of Biochemistry and Molecular Biology, Federal University of Paraná, CP 19.046, CEP 81.531-980 Curitiba, PR, BrazilDepartment of Pharmacology, Federal University of Paraná, CEP 81.531-980 Curitiba, PR, BrazilDepartment of Pharmacology, Federal University of Paraná, CEP 81.531-980 Curitiba, PR, BrazilDepartment of Pharmacology, Federal University of Paraná, CEP 81.531-980 Curitiba, PR, BrazilDepartment of Food and Nutrition, School of Food Engineering, University of Campinas, CEP 13083-862 Campinas, SP, BrazilDepartment of Food and Nutrition, School of Food Engineering, University of Campinas, CEP 13083-862 Campinas, SP, BrazilDepartment of Biochemistry and Molecular Biology, Federal University of Paraná, CP 19.046, CEP 81.531-980 Curitiba, PR, BrazilDepartment of Biochemistry and Molecular Biology, Federal University of Paraná, CP 19.046, CEP 81.531-980 Curitiba, PR, Brazil; Corresponding author.Yellow passion fruit peel (PFP) is considered an important source of dietary fibre (DF) and its consumption has been associated with health benefits in metabolic and gut disturbs. This work aimed to characterize the chemical structure of soluble DF (SDF) from PFP and evaluate its gastroprotective activity in acute gastric-ulcer model induced by ethanol in rats. SDF was composed of 92% of GalA and presented high methyl esterified homogalacturonan (DE = 70%), with relative Mw of 53 kDa. Oral pre-treatment of animals with SDF (0.1, 1 and 10 mg/kg) significantly reduced gastric ulcer lesions by 72%, 79% and 87% respectively. The gastroprotective effect was maintained when SDF was administered by the intraperitoneal route. SDF also prevented the depletion of GSH levels and gastric wall mucus when administered by both routes. These results demonstrated that ingestion of SDF from PFP exerts significant gastroprotective effects in vivo on experimentally induced gastric ulcers.http://www.sciencedirect.com/science/article/pii/S1756464619300660Soluble dietary fibrePectinYellow passion fruit peelAnti-ulcer effect |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kahlile Youssef Abboud Bruna Barbosa da Luz Jorge Luiz Dallazen Maria Fernanda de Paula Werner Cinthia Baú Betim Cazarin Mário Roberto Maróstica Junior Marcello Iacomini Lucimara M.C. Cordeiro |
spellingShingle |
Kahlile Youssef Abboud Bruna Barbosa da Luz Jorge Luiz Dallazen Maria Fernanda de Paula Werner Cinthia Baú Betim Cazarin Mário Roberto Maróstica Junior Marcello Iacomini Lucimara M.C. Cordeiro Gastroprotective effect of soluble dietary fibres from yellow passion fruit (Passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in rats Journal of Functional Foods Soluble dietary fibre Pectin Yellow passion fruit peel Anti-ulcer effect |
author_facet |
Kahlile Youssef Abboud Bruna Barbosa da Luz Jorge Luiz Dallazen Maria Fernanda de Paula Werner Cinthia Baú Betim Cazarin Mário Roberto Maróstica Junior Marcello Iacomini Lucimara M.C. Cordeiro |
author_sort |
Kahlile Youssef Abboud |
title |
Gastroprotective effect of soluble dietary fibres from yellow passion fruit (Passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in rats |
title_short |
Gastroprotective effect of soluble dietary fibres from yellow passion fruit (Passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in rats |
title_full |
Gastroprotective effect of soluble dietary fibres from yellow passion fruit (Passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in rats |
title_fullStr |
Gastroprotective effect of soluble dietary fibres from yellow passion fruit (Passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in rats |
title_full_unstemmed |
Gastroprotective effect of soluble dietary fibres from yellow passion fruit (Passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in rats |
title_sort |
gastroprotective effect of soluble dietary fibres from yellow passion fruit (passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in rats |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2019-03-01 |
description |
Yellow passion fruit peel (PFP) is considered an important source of dietary fibre (DF) and its consumption has been associated with health benefits in metabolic and gut disturbs. This work aimed to characterize the chemical structure of soluble DF (SDF) from PFP and evaluate its gastroprotective activity in acute gastric-ulcer model induced by ethanol in rats. SDF was composed of 92% of GalA and presented high methyl esterified homogalacturonan (DE = 70%), with relative Mw of 53 kDa. Oral pre-treatment of animals with SDF (0.1, 1 and 10 mg/kg) significantly reduced gastric ulcer lesions by 72%, 79% and 87% respectively. The gastroprotective effect was maintained when SDF was administered by the intraperitoneal route. SDF also prevented the depletion of GSH levels and gastric wall mucus when administered by both routes. These results demonstrated that ingestion of SDF from PFP exerts significant gastroprotective effects in vivo on experimentally induced gastric ulcers. |
topic |
Soluble dietary fibre Pectin Yellow passion fruit peel Anti-ulcer effect |
url |
http://www.sciencedirect.com/science/article/pii/S1756464619300660 |
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