High stress hormone levels accelerate the onset of memory deficits in male Huntington's disease mice

High stress hormone levels accelerate the onset of memory deficits in male Huntington's disease mice

Huntington's disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation in the huntingtin gene. Lifestyle factors, such as lack of activity may contribute to the variability in the age of disease onset. Therefore, better understanding of environmental modifiers may uncover...

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Bibliographic Details
Main Authors: Christina Mo, Terence Y. Pang, Mark I. Ransome, Rachel A. Hill, Thibault Renoir, Anthony J. Hannan
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Corticosterone treatment
Stress hormone
Short-term memory
HPA axis
Cell proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001144

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