Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge
Implant infection is the most common mode of joint replacement failure with serious complications. Here, the authors report on the in vivo application of a prophylactic coating technology that can incorporate a range of antibiotics and be applied in the operating room prior to implantation.
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| Format: | Article |
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Nature Publishing Group
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25383-z |
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doaj-76aa4dbb4edd442f94aaa3e0f4b4b4882021-09-19T11:49:31ZengNature Publishing GroupNature Communications2041-17232021-09-0112111510.1038/s41467-021-25383-zPoint-of-care antimicrobial coating protects orthopaedic implants from bacterial challengeWeixian Xi0Vishal Hegde1Stephen D. Zoller2Howard Y. Park3Christopher M. Hart4Takeru Kondo5Christopher D. Hamad6Yan Hu7Amanda H. Loftin8Daniel O. Johansen9Zachary Burke10Samuel Clarkson11Chad Ishmael12Kellyn Hori13Zeinab Mamouei14Hiroko Okawa15Ichiro Nishimura16Nicholas M. Bernthal17Tatiana Segura18Department of Chemical and Biomolecular Engineering, University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesWeintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, University of California Los Angeles School of DentistryDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesWeintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, University of California Los Angeles School of DentistryWeintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, University of California Los Angeles School of DentistryDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los AngelesDepartment of Chemical and Biomolecular Engineering, University of California Los AngelesImplant infection is the most common mode of joint replacement failure with serious complications. Here, the authors report on the in vivo application of a prophylactic coating technology that can incorporate a range of antibiotics and be applied in the operating room prior to implantation.https://doi.org/10.1038/s41467-021-25383-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Weixian Xi Vishal Hegde Stephen D. Zoller Howard Y. Park Christopher M. Hart Takeru Kondo Christopher D. Hamad Yan Hu Amanda H. Loftin Daniel O. Johansen Zachary Burke Samuel Clarkson Chad Ishmael Kellyn Hori Zeinab Mamouei Hiroko Okawa Ichiro Nishimura Nicholas M. Bernthal Tatiana Segura |
| spellingShingle |
Weixian Xi Vishal Hegde Stephen D. Zoller Howard Y. Park Christopher M. Hart Takeru Kondo Christopher D. Hamad Yan Hu Amanda H. Loftin Daniel O. Johansen Zachary Burke Samuel Clarkson Chad Ishmael Kellyn Hori Zeinab Mamouei Hiroko Okawa Ichiro Nishimura Nicholas M. Bernthal Tatiana Segura Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge Nature Communications |
| author_facet |
Weixian Xi Vishal Hegde Stephen D. Zoller Howard Y. Park Christopher M. Hart Takeru Kondo Christopher D. Hamad Yan Hu Amanda H. Loftin Daniel O. Johansen Zachary Burke Samuel Clarkson Chad Ishmael Kellyn Hori Zeinab Mamouei Hiroko Okawa Ichiro Nishimura Nicholas M. Bernthal Tatiana Segura |
| author_sort |
Weixian Xi |
| title |
Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge |
| title_short |
Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge |
| title_full |
Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge |
| title_fullStr |
Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge |
| title_full_unstemmed |
Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge |
| title_sort |
point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-09-01 |
| description |
Implant infection is the most common mode of joint replacement failure with serious complications. Here, the authors report on the in vivo application of a prophylactic coating technology that can incorporate a range of antibiotics and be applied in the operating room prior to implantation. |
| url |
https://doi.org/10.1038/s41467-021-25383-z |
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