Systemically Administered Homing Peptide Targets Dystrophic Lesions and Delivers Transforming Growth Factor-β (TGFβ) Inhibitor to Attenuate Murine Muscular Dystrophy Pathology

Systemically Administered Homing Peptide Targets Dystrophic Lesions and Delivers Transforming Growth Factor-β (TGFβ) Inhibitor to Attenuate Murine Muscular Dystrophy Pathology

Muscular dystrophy is a progressively worsening and lethal disease, where accumulation of functionality-impairing fibrosis plays a key pathogenic role. Transforming growth factor-β1 (TGFβ1) is a central signaling molecule in the development of fibrosis in muscular dystrophic humans and mice. Inhibit...

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Bibliographic Details
Main Authors: Aqsa Iqbal, Ulrike May, Stuart N. Prince, Tero A.H. Järvinen, Ahlke Heydemann
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceutics
Subjects:
vascular homing peptide
muscular dystrophy
fibrosis
transforming growth factor-β1 (TGFβ1)
decorin
mdx
Online Access:https://www.mdpi.com/1999-4923/13/9/1506

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