Periprosthetic bone loss: diagnostic and therapeutic approaches [v2; ref status: indexed, http://f1000r.es/3pz]
Total joint replacement surgery is being performed on an increasingly large part of the population. Clinical longevity of implants depends on their osseointegration, which is influenced by the load, the characteristics of the implant and the bone-implant interface, as well as by the quality and quan...
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doaj-76b2c827419e489b9520efd0b527426b2020-11-25T03:12:37ZengF1000 Research LtdF1000Research2046-14022014-06-01210.12688/f1000research.2-266.v24823Periprosthetic bone loss: diagnostic and therapeutic approaches [v2; ref status: indexed, http://f1000r.es/3pz]Loredana Cavalli0Maria Luisa Brandi1Department of Surgery and Translational Medicine, University of Florence, Florence, 50139, ItalyDepartment of Surgery and Translational Medicine, University of Florence, Florence, 50139, ItalyTotal joint replacement surgery is being performed on an increasingly large part of the population. Clinical longevity of implants depends on their osseointegration, which is influenced by the load, the characteristics of the implant and the bone-implant interface, as well as by the quality and quantity of the surrounding bone. Aseptic loosening due to periprosthetic osteolysis is the most frequent known cause of implant failure. Wear of prosthetic materials results in the formation of numerous particles of debris that cause a complex biological response. Dual-energy X-ray Absorptiometry (DXA) is regarded as an accurate method to evaluate Bone Mineral Density (BMD) around hip or knee prostheses. Further data may be provided by a new device, the Bone Microarchitecture Analysis (BMA), which combines bone microarchitecture quantification and ultra high resolution osteo-articular imaging. Pharmacological strategies have been developed to prevent bone mass loss and to extend implant survival. Numerous trials with bisphosphonates show a protective effect on periprosthetic bone mass, up to 72 months after arthroplasty. Strontium ranelate has been demonstrated to increase the osseointegration of titanium implants in treated animals with improvement of bone microarchitecture and bone biomaterial properties.http://f1000research.com/articles/2-266/v2Bone Biology, Osteoporosis & Other Diseases of Bone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Loredana Cavalli Maria Luisa Brandi |
spellingShingle |
Loredana Cavalli Maria Luisa Brandi Periprosthetic bone loss: diagnostic and therapeutic approaches [v2; ref status: indexed, http://f1000r.es/3pz] F1000Research Bone Biology, Osteoporosis & Other Diseases of Bone |
author_facet |
Loredana Cavalli Maria Luisa Brandi |
author_sort |
Loredana Cavalli |
title |
Periprosthetic bone loss: diagnostic and therapeutic approaches [v2; ref status: indexed, http://f1000r.es/3pz] |
title_short |
Periprosthetic bone loss: diagnostic and therapeutic approaches [v2; ref status: indexed, http://f1000r.es/3pz] |
title_full |
Periprosthetic bone loss: diagnostic and therapeutic approaches [v2; ref status: indexed, http://f1000r.es/3pz] |
title_fullStr |
Periprosthetic bone loss: diagnostic and therapeutic approaches [v2; ref status: indexed, http://f1000r.es/3pz] |
title_full_unstemmed |
Periprosthetic bone loss: diagnostic and therapeutic approaches [v2; ref status: indexed, http://f1000r.es/3pz] |
title_sort |
periprosthetic bone loss: diagnostic and therapeutic approaches [v2; ref status: indexed, http://f1000r.es/3pz] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2014-06-01 |
description |
Total joint replacement surgery is being performed on an increasingly large part of the population. Clinical longevity of implants depends on their osseointegration, which is influenced by the load, the characteristics of the implant and the bone-implant interface, as well as by the quality and quantity of the surrounding bone. Aseptic loosening due to periprosthetic osteolysis is the most frequent known cause of implant failure. Wear of prosthetic materials results in the formation of numerous particles of debris that cause a complex biological response. Dual-energy X-ray Absorptiometry (DXA) is regarded as an accurate method to evaluate Bone Mineral Density (BMD) around hip or knee prostheses. Further data may be provided by a new device, the Bone Microarchitecture Analysis (BMA), which combines bone microarchitecture quantification and ultra high resolution osteo-articular imaging. Pharmacological strategies have been developed to prevent bone mass loss and to extend implant survival. Numerous trials with bisphosphonates show a protective effect on periprosthetic bone mass, up to 72 months after arthroplasty. Strontium ranelate has been demonstrated to increase the osseointegration of titanium implants in treated animals with improvement of bone microarchitecture and bone biomaterial properties. |
topic |
Bone Biology, Osteoporosis & Other Diseases of Bone |
url |
http://f1000research.com/articles/2-266/v2 |
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