Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues

Abstract Clinical use of polygenic risk scores (PRS) will look very different to the more familiar monogenic testing. Here we argue that despite these differences, most of the ethical, legal, and social issues (ELSI) raised in the monogenic setting, such as the relevance of results to family members...

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Bibliographic Details
Main Authors: Anna C. F. Lewis, Robert C. Green
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Genome Medicine
Online Access:https://doi.org/10.1186/s13073-021-00829-7