Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience
<h4>Background</h4> Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing to their immunosuppressed state and propensity for kidney injury. The primary purpose of this study is to ascertain if, in kidney transplant recipients,...
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doaj-76bd8032da084b579721b66c402f8de92021-06-13T04:30:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01166Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experienceSkylar L. NahiAneesha A. ShettySajal D. TannaJoseph R. Leventhal<h4>Background</h4> Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing to their immunosuppressed state and propensity for kidney injury. The primary purpose of this study is to ascertain if, in kidney transplant recipients, SARS-CoV 2 infection impacts long term renal allograft function. <h4>Methods</h4> This retrospective, single-center study reviewed 53 kidney transplant recipients with a positive SARS-CoV-2 PCR at NMH from January 1, 2020 to June 30, 2020. <h4>Results</h4> Change in eGFR from baseline kidney function prior to infection to 90 days after the first positive SARS-CoV 2 test was +1.76%, -17.5% and -23.16% the mild, moderate and severe disease groups respectively. There was a significant decline in kidney function in the moderate and severe disease cohorts as compared to the mild disease cohort, with respective p values of p = 0.0002 and p = 0.021. Relative to the mild disease cohort, the moderate and severe disease cohorts also demonstrated significantly increased risk of developing AKI (66%, 85%), both with p values of P = 0.0001. <h4>Conclusions</h4> Clinically severe SARS-CoV 2 infection is associated with greater risk of acute kidney injury and greater decline in renal allograft function at 90 days post infection, compared to mild disease.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191896/?tool=EBI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Skylar L. Nahi Aneesha A. Shetty Sajal D. Tanna Joseph R. Leventhal |
spellingShingle |
Skylar L. Nahi Aneesha A. Shetty Sajal D. Tanna Joseph R. Leventhal Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience PLoS ONE |
author_facet |
Skylar L. Nahi Aneesha A. Shetty Sajal D. Tanna Joseph R. Leventhal |
author_sort |
Skylar L. Nahi |
title |
Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience |
title_short |
Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience |
title_full |
Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience |
title_fullStr |
Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience |
title_full_unstemmed |
Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience |
title_sort |
renal allograft function in kidney transplant recipients infected with sars-cov 2: an academic single center experience |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2021-01-01 |
description |
<h4>Background</h4> Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing to their immunosuppressed state and propensity for kidney injury. The primary purpose of this study is to ascertain if, in kidney transplant recipients, SARS-CoV 2 infection impacts long term renal allograft function. <h4>Methods</h4> This retrospective, single-center study reviewed 53 kidney transplant recipients with a positive SARS-CoV-2 PCR at NMH from January 1, 2020 to June 30, 2020. <h4>Results</h4> Change in eGFR from baseline kidney function prior to infection to 90 days after the first positive SARS-CoV 2 test was +1.76%, -17.5% and -23.16% the mild, moderate and severe disease groups respectively. There was a significant decline in kidney function in the moderate and severe disease cohorts as compared to the mild disease cohort, with respective p values of p = 0.0002 and p = 0.021. Relative to the mild disease cohort, the moderate and severe disease cohorts also demonstrated significantly increased risk of developing AKI (66%, 85%), both with p values of P = 0.0001. <h4>Conclusions</h4> Clinically severe SARS-CoV 2 infection is associated with greater risk of acute kidney injury and greater decline in renal allograft function at 90 days post infection, compared to mild disease. |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191896/?tool=EBI |
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