2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) activates Aryl hydrocarbon receptor (AhR) mediated ROS and NLRP3 inflammasome/p38 MAPK pathway inducing necrosis in cochlear hair cells

2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) activates Aryl hydrocarbon receptor (AhR) mediated ROS and NLRP3 inflammasome/p38 MAPK pathway inducing necrosis in cochlear hair cells

Tetrabromodiphenyl ether (BDE-47) is widely used as commercial flame retardants that can be released into the environment and finally enter human body through the food chain. It has been identified to generate neurotoxicity, but little is known about auditory damage and the underlying mechanism foll...

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Bibliographic Details
Main Authors: Jie Tang, Bo Hu, Huaping Zheng, Xiaolan Qian, Yi Zhang, Jia Zhu, Guangtao Xu, Deqing Chen, Xin Jin, Wanlu Li, Long Xu
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Aryl hydrocarbon receptor
BDE-47
HEI-OC1 cells
Necrosis
NLRP3 inflammasome
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321005352

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http://www.sciencedirect.com/science/article/pii/S0147651321005352

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