Plastin 3 Expression Does Not Modify Spinal Muscular Atrophy Severity in the ∆7 SMA Mouse.

Plastin 3 Expression Does Not Modify Spinal Muscular Atrophy Severity in the ∆7 SMA Mouse.

Spinal muscular atrophy is caused by loss of the SMN1 gene and retention of SMN2. The SMN2 copy number inversely correlates with phenotypic severity and is a modifier of disease outcome. The SMN2 gene essentially differs from SMN1 by a single nucleotide in exon 7 that modulates the incorporation of...

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Bibliographic Details
Main Authors: Vicki L McGovern, Aurélie Massoni-Laporte, Xueyong Wang, Thanh T Le, Hao T Le, Christine E Beattie, Mark M Rich, Arthur H M Burghes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4489873?pdf=render

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http://europepmc.org/articles/PMC4489873?pdf=render

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