Cell-Type-Specific Proteogenomic Signal Diffusion for Integrating Multi-Omics Data Predicts Novel Schizophrenia Risk Genes

Cell-Type-Specific Proteogenomic Signal Diffusion for Integrating Multi-Omics Data Predicts Novel Schizophrenia Risk Genes

Summary: Accumulation of diverse types of omics data on schizophrenia (SCZ) requires a systems approach to model the interplay between genome, transcriptome, and proteome. We introduce Markov affinity-based proteogenomic signal diffusion (MAPSD), a method to model intra-cellular protein trafficking...

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Bibliographic Details
Main Authors: Abolfazl Doostparast Torshizi, Jubao Duan, Kai Wang
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Patterns
Subjects:
signal diffusion
protein-protein interaction
interaction networks
proteome
multi-omics
schizophrenia
Online Access:http://www.sciencedirect.com/science/article/pii/S2666389920301197

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http://www.sciencedirect.com/science/article/pii/S2666389920301197

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