Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?
Accumulating evidence from animal and human studies supports the notion that physical exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative diseases (e.g., dementia). However, the underlying neurobiological mechanisms of exercise induced neuroplasticity are still...
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doaj-76c733ff1dc9428887e259897e30f1922020-11-25T03:05:53ZengMDPI AGJournal of Clinical Medicine2077-03832020-04-0191136113610.3390/jcm9041136Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?Patrick Müller0Yves Duderstadt1Volkmar Lessmann2Notger G. Müller3Research Group Neuroprotection, German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120 Magdeburg, GermanyResearch Group Neuroprotection, German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120 Magdeburg, GermanyMedical Faculty, Institute of Physiology, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, GermanyResearch Group Neuroprotection, German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120 Magdeburg, GermanyAccumulating evidence from animal and human studies supports the notion that physical exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative diseases (e.g., dementia). However, the underlying neurobiological mechanisms of exercise induced neuroplasticity are still largely unknown. One potential mediator of exercise effects is the neurotrophin BDNF, which enhances neuroplasticity via different pathways (e.g., synaptogenesis, neurogenesis, long-term potentiation). Current research has shown that (i) increased peripheral lactate levels (following high intensity exercise) are associated with increased peripheral BDNF levels, (ii) lactate infusion at rest can increase peripheral and central BDNF levels and (iii) lactate plays a very complex role in the brain’s metabolism. In this review, we summarize the role and relationship of lactate and BDNF in exercise induced neuroplasticity.https://www.mdpi.com/2077-0383/9/4/1136physical exerciseBDNFlactateneuroplasticity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Patrick Müller Yves Duderstadt Volkmar Lessmann Notger G. Müller |
spellingShingle |
Patrick Müller Yves Duderstadt Volkmar Lessmann Notger G. Müller Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity? Journal of Clinical Medicine physical exercise BDNF lactate neuroplasticity |
author_facet |
Patrick Müller Yves Duderstadt Volkmar Lessmann Notger G. Müller |
author_sort |
Patrick Müller |
title |
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity? |
title_short |
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity? |
title_full |
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity? |
title_fullStr |
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity? |
title_full_unstemmed |
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity? |
title_sort |
lactate and bdnf: key mediators of exercise induced neuroplasticity? |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-04-01 |
description |
Accumulating evidence from animal and human studies supports the notion that physical exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative diseases (e.g., dementia). However, the underlying neurobiological mechanisms of exercise induced neuroplasticity are still largely unknown. One potential mediator of exercise effects is the neurotrophin BDNF, which enhances neuroplasticity via different pathways (e.g., synaptogenesis, neurogenesis, long-term potentiation). Current research has shown that (i) increased peripheral lactate levels (following high intensity exercise) are associated with increased peripheral BDNF levels, (ii) lactate infusion at rest can increase peripheral and central BDNF levels and (iii) lactate plays a very complex role in the brain’s metabolism. In this review, we summarize the role and relationship of lactate and BDNF in exercise induced neuroplasticity. |
topic |
physical exercise BDNF lactate neuroplasticity |
url |
https://www.mdpi.com/2077-0383/9/4/1136 |
work_keys_str_mv |
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