Astrocytes in Neuropathologies Affecting the Frontal Cortex
To an increasing extent, astrocytes are connected with various neuropathologies. Astrocytes comprise of a heterogeneous population of cells with region- and species-specific properties. The frontal cortex exhibits high levels of plasticity that is required for high cognitive functions and memory mak...
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Frontiers Media S.A.
2019-02-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00044/full |
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doaj-76cf5a1db94648adaceda30ef12069e72020-11-25T02:15:00ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-02-011310.3389/fncel.2019.00044434263Astrocytes in Neuropathologies Affecting the Frontal CortexUlla-Kaisa PeteriMikael NiukkanenMaija L. CastrénTo an increasing extent, astrocytes are connected with various neuropathologies. Astrocytes comprise of a heterogeneous population of cells with region- and species-specific properties. The frontal cortex exhibits high levels of plasticity that is required for high cognitive functions and memory making this region especially susceptible to damage. Aberrations in the frontal cortex are involved with several cognitive disorders, including Alzheimer’s disease, Huntington’s disease and frontotemporal dementia. Human induced pluripotent stem cells (iPSCs) provide an alternative for disease modeling and offer possibilities for studies to investigate pathological mechanisms in a cell type-specific manner. Patient-specific iPSC-derived astrocytes have been shown to recapitulate several disease phenotypes. Addressing astrocyte heterogeneity may provide an improved understanding of the mechanisms underlying neurodegenerative diseases.https://www.frontiersin.org/article/10.3389/fncel.2019.00044/fullastrocytefrontal cortexAlzheimer’s diseaseHuntington’s diseasefrontotemporal dementianeurodegeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ulla-Kaisa Peteri Mikael Niukkanen Maija L. Castrén |
spellingShingle |
Ulla-Kaisa Peteri Mikael Niukkanen Maija L. Castrén Astrocytes in Neuropathologies Affecting the Frontal Cortex Frontiers in Cellular Neuroscience astrocyte frontal cortex Alzheimer’s disease Huntington’s disease frontotemporal dementia neurodegeneration |
author_facet |
Ulla-Kaisa Peteri Mikael Niukkanen Maija L. Castrén |
author_sort |
Ulla-Kaisa Peteri |
title |
Astrocytes in Neuropathologies Affecting the Frontal Cortex |
title_short |
Astrocytes in Neuropathologies Affecting the Frontal Cortex |
title_full |
Astrocytes in Neuropathologies Affecting the Frontal Cortex |
title_fullStr |
Astrocytes in Neuropathologies Affecting the Frontal Cortex |
title_full_unstemmed |
Astrocytes in Neuropathologies Affecting the Frontal Cortex |
title_sort |
astrocytes in neuropathologies affecting the frontal cortex |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2019-02-01 |
description |
To an increasing extent, astrocytes are connected with various neuropathologies. Astrocytes comprise of a heterogeneous population of cells with region- and species-specific properties. The frontal cortex exhibits high levels of plasticity that is required for high cognitive functions and memory making this region especially susceptible to damage. Aberrations in the frontal cortex are involved with several cognitive disorders, including Alzheimer’s disease, Huntington’s disease and frontotemporal dementia. Human induced pluripotent stem cells (iPSCs) provide an alternative for disease modeling and offer possibilities for studies to investigate pathological mechanisms in a cell type-specific manner. Patient-specific iPSC-derived astrocytes have been shown to recapitulate several disease phenotypes. Addressing astrocyte heterogeneity may provide an improved understanding of the mechanisms underlying neurodegenerative diseases. |
topic |
astrocyte frontal cortex Alzheimer’s disease Huntington’s disease frontotemporal dementia neurodegeneration |
url |
https://www.frontiersin.org/article/10.3389/fncel.2019.00044/full |
work_keys_str_mv |
AT ullakaisapeteri astrocytesinneuropathologiesaffectingthefrontalcortex AT mikaelniukkanen astrocytesinneuropathologiesaffectingthefrontalcortex AT maijalcastren astrocytesinneuropathologiesaffectingthefrontalcortex |
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1724898488459722752 |