Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study
<p>Abstract</p> <p>Background</p> <p>The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and...
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doaj-76e177f5335243b29ca57bd52bf948ec2021-04-02T17:43:11ZengBMCBMC Medical Genetics1471-23502012-08-011316610.1186/1471-2350-13-66Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control studyNilsson DanielAndiappan AnandHalldén ChristerDe Yun WangSäll TorbjörnTim ChewCardell Lars-Olaf<p>Abstract</p> <p>Background</p> <p>The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and allergic disorders such as asthma and allergic rhinitis. The present study aim to search for genetic variation associated with allergic rhinitis in the Toll-like receptor genes.</p> <p>Methods</p> <p>A first association analysis genotyped 73 SNPs in 182 cases and 378 controls from a Swedish population. Based on these results an additional 24 SNPs were analyzed in one Swedish population with 352 cases and 709 controls and one Chinese population with 948 cases and 580 controls.</p> <p>Results</p> <p>The first association analysis identified 4 allergic rhinitis-associated SNPs in the <it>TLR7-TLR8</it> gene region. Subsequent analysis of 24 SNPs from this region identified 7 and 5 significant SNPs from the Swedish and Chinese populations, respectively. The corresponding risk-associated haplotypes are significant after Bonferroni correction and are the most common haplotypes in both populations. The associations are primarily detected in females in the Swedish population, whereas it is seen in males in the Chinese population. Further independent support for the involvement of this region in allergic rhinitis was obtained from quantitative skin prick test data generated in both populations.</p> <p>Conclusions</p> <p>Haplotypes in the <it>TLR7-TLR8</it> gene region were associated with allergic rhinitis in one Swedish and one Chinese population. Since this region has earlier been associated with asthma and allergic rhinitis in a Danish linkage study this speaks strongly in favour of this region being truly involved in the development of this disease.</p> http://www.biomedcentral.com/1471-2350/13/66Allergic rhinitisToll-like receptorPolymorphismGeneticsHaplotypeCase–control |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nilsson Daniel Andiappan Anand Halldén Christer De Yun Wang Säll Torbjörn Tim Chew Cardell Lars-Olaf |
spellingShingle |
Nilsson Daniel Andiappan Anand Halldén Christer De Yun Wang Säll Torbjörn Tim Chew Cardell Lars-Olaf Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study BMC Medical Genetics Allergic rhinitis Toll-like receptor Polymorphism Genetics Haplotype Case–control |
author_facet |
Nilsson Daniel Andiappan Anand Halldén Christer De Yun Wang Säll Torbjörn Tim Chew Cardell Lars-Olaf |
author_sort |
Nilsson Daniel |
title |
Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study |
title_short |
Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study |
title_full |
Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study |
title_fullStr |
Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study |
title_full_unstemmed |
Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study |
title_sort |
toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study |
publisher |
BMC |
series |
BMC Medical Genetics |
issn |
1471-2350 |
publishDate |
2012-08-01 |
description |
<p>Abstract</p> <p>Background</p> <p>The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and allergic disorders such as asthma and allergic rhinitis. The present study aim to search for genetic variation associated with allergic rhinitis in the Toll-like receptor genes.</p> <p>Methods</p> <p>A first association analysis genotyped 73 SNPs in 182 cases and 378 controls from a Swedish population. Based on these results an additional 24 SNPs were analyzed in one Swedish population with 352 cases and 709 controls and one Chinese population with 948 cases and 580 controls.</p> <p>Results</p> <p>The first association analysis identified 4 allergic rhinitis-associated SNPs in the <it>TLR7-TLR8</it> gene region. Subsequent analysis of 24 SNPs from this region identified 7 and 5 significant SNPs from the Swedish and Chinese populations, respectively. The corresponding risk-associated haplotypes are significant after Bonferroni correction and are the most common haplotypes in both populations. The associations are primarily detected in females in the Swedish population, whereas it is seen in males in the Chinese population. Further independent support for the involvement of this region in allergic rhinitis was obtained from quantitative skin prick test data generated in both populations.</p> <p>Conclusions</p> <p>Haplotypes in the <it>TLR7-TLR8</it> gene region were associated with allergic rhinitis in one Swedish and one Chinese population. Since this region has earlier been associated with asthma and allergic rhinitis in a Danish linkage study this speaks strongly in favour of this region being truly involved in the development of this disease.</p> |
topic |
Allergic rhinitis Toll-like receptor Polymorphism Genetics Haplotype Case–control |
url |
http://www.biomedcentral.com/1471-2350/13/66 |
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